Results 81 to 90 of about 219,974 (370)

Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease

Advanced Therapeutics, EarlyView.
An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang, Xudong Lin, Kai Xie, Zixun Wang, Tianying Sun, Zhen Xu, Haibing Yue, Xi Chen, Qinghai Liao, Ming Liu, Wing Ho Yung, Jufang He, Feng Wang, Peng Shi   +13 more
wiley   +1 more source

Streptococcus pneumoniae Serotypes Associated with Death, South Africa, 2012–2018

Emerging Infectious Diseases, 2022
The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012–2018 (vaccine era ...
Annelies Müller, Jackie Kleynhans, Linda de Gouveia, Susan Meiring, Cheryl Cohen, Lucy Jane Hathaway, Anne von Gottberg   +6 more
doaj   +1 more source

Markovian approach to tackle the interaction of simultaneous diseases [PDF]

Phys. Rev. E 100, 062308 (2019), 2019
The simultaneous emergence of several abrupt disease outbreaks or the extinction of some serotypes of multi-strain diseases are fingerprints of the interaction between pathogens spreading within the same population. Here, we propose a general and versatile benchmark to address the unfolding of both cooperative and competitive interacting diseases.
arxiv   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Variation in the nuclear effects of infection by different human rhinovirus serotypes.

Frontiers in Microbiology, 2015
Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localisation of host proteins.
Erin Joanne Walker, Lora M Jensen, Sarah N Croft, Reena eGhildyal   +3 more
doaj   +1 more source

Microarray for serotyping of Bartonella species [PDF]

BMC Microbiology, 2007
AbstractBackgroundBacteria of the genusBartonellaare responsible for a large variety of human and animal diseases. Serological typing ofBartonellais a method that can be used for differentiation and identification ofBartonellasubspecies.ResultsWe have developed a novel multiple antigenic microarray to serotypeBartonellastrains and to select poly and ...
Cyrille J. Bonhomme, Didier Raoult, Claude Nappez   +2 more
openaire   +4 more sources

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, EarlyView.
Macrophages play a critical role in several pathophysiological diseases by being involved in the activation of adaptive and innate immune responses. The repolarization of macrophages using gold nanoparticles functionalized with glycans for a more selective targeting toward a restorative phenotype leads to an amelioration of the events.
Jennifer Fernandez Alarcon, Patricia Perez Schmidt, Nicolo Panini, Francesca Caruso, Martina B. Violatto, Naths Grazia Sukubo, Alberto Martinez‐Serra, Charlotte Blanche Ekalle‐Soppo, Annalisa Morelli, Giulia Yuri Moscatiello, Chiara Grasselli, Alessandro Corbelli, Fabio Fiordaliso, Joe Kelk, Laura Petrosilli, Giuseppe d'Orazio, Ruth Mateu Ferrando, Ariadna Verdaguer Ferrer, Cristina Fornaguera, Luigi Lay, Stefano Fumagalli, Sandro Recchia, Marco P. Monopoli, Laura Polito, Paolo Bigini, Giovanni Sitia   +25 more
wiley   +1 more source

Invasive Group B Streptococcal Infection in Infants, Malawi

Emerging Infectious Diseases, 2007
Group B streptococci (GBS) are a recently identified cause of neonatal sepsis in Malawi. In Queen Elizabeth Central Hospital, Blantyre, Malawi, during May 2004–June 2005, GBS were isolated from routine blood and cerebrospinal fluid cultures from 57 ...
Katherine J. Gray, Sally L. Bennett, Neil French, Amos J. Phiri, Stephen M. Graham   +4 more
doaj   +1 more source

Robust AAV Genotyping Based on Genetic Distances in Rep Gene That Are Maintained by Ubiquitous Recombination

Viruses, 2022
Adeno-associated viruses (AAVs) are a convenient tool for gene therapy delivery. According to the current classification, they are divided into the species AAV A and AAV B within the genus Dependoparvovirus.
Marina I. Beloukhova, Alexander N. Lukashev, Pavel Y. Volchkov, Andrey A. Zamyatnin, Andrei A. Deviatkin   +4 more
doaj   +1 more source

Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany

PLoS ONE, 2015
This study describes the effects of the introduction of universal infant pneumococcal conjugate vaccination in 2006 on invasive pneumococcal disease (IPD) among children and adults in Germany with a focus on the dynamics of serotype distribution in ...
M. P. van der Linden, G. Falkenhorst, S. Perniciaro, M. Imöhl   +3 more
semanticscholar   +1 more source