Results 51 to 60 of about 52,285 (258)

EPIZOOTIOLOGY AND CONTROL MEASUREMENTS OF FOOT AND MOUTH DISEASE (FMD) IN SAUDI ARABIA FROM 1999 TO 2004 [PDF]

Assiut Veterinary Medical Journal, 2005
Over a period of five years from July 1999 to June 2004, five outbreaks of FMD serotype O and one outbreak of FMD serotype SAT 2 were reported among livestock in Saudi Arabia.
M.H. ABDEL BAKY, I.H.A. ABD EL-RAHIM, A.R. HABASHI, M.M. MAHMOUD, D.M. AL-MUJALII   +4 more
doaj   +1 more source

Strain Characterization of Streptococcus suis Serotypes 28 and 31, Which Harbor the Resistance Genes optrA and ant(6)-Ia

Pathogens, 2021
Streptococcus suis causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of
Shujie Wang, Defu Zhang, Chenggang Jiang, Haijuan He, Chenchen Cui, Weitong Duan, Shouping Hu, Jun Wang, Xuehui Cai   +8 more
doaj   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B

Microbiology Spectrum
ABSTRACT The polysaccharide (PS) capsule of Streptococcus pneumoniae (pneumococcus) is the immunodominant surface structure that shields the bacteria from the host immune system.
Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm   +8 more
openaire   +3 more sources

O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a [PDF]

Carbohydrate Research, 2007
Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide ...
Kubler-Kielb, J., Vinogradov, Evguenii, Chu, C., Schneerson, R.   +3 more
openaire   +3 more sources

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence.

PLoS Pathogens
Evolution of the highly successful and multidrug resistant clone ST111 in Pseudomonas aeruginosa involves serotype switching from O-antigen O4 to O12.
Mikkel Anbo, Mahbuba Akter Lubna, Dina A Moustafa, Telmo O Paiva, Laura Serioli, Kinga Zor, Claus Sternberg, Katy Jeannot, Oana Ciofu, Yves F Dufrêne, Joanna B Goldberg, Lars Jelsbak   +11 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Phylogenetic analyses of the polyprotein coding sequences of serotype O foot-and-mouth disease viruses in East Africa: evidence for interserotypic recombination

Virology Journal, 2010
Background Foot-and-mouth disease (FMD) is endemic in East Africa with the majority of the reported outbreaks attributed to serotype O virus. In this study, phylogenetic analyses of the polyprotein coding region of serotype O FMD viruses from Kenya and ...
Balinda Sheila N, Siegismund Hans R, Muwanika Vincent B, Sangula Abraham K, Masembe Charles, Ayebazibwe Chrisostom, Normann Preben, Belsham Graham J   +7 more
doaj   +1 more source