Results 181 to 190 of about 192,156 (336)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

PacBio Genome Sequences of Escherichia coli Serotype O157:H7, Diffusely Adherent E. coli, and Salmonella enterica Strains, All Carrying Plasmids with an mcr-1 Resistance Gene

, 2018
Rebecca L. Lindsey, Dhwani Batra, P. B. Smith, Pooja N. Patel, Kaitlin A. Tagg, Lisley Garcia-Toledo, Vladimir N. Loparev, Phalasy Juieng, Mili Sheth, Yoo Jin Joung, Lori A. Rowe   +10 more
openalex   +1 more source

119. Long-Term Correction of Hyperphenylalaninemia in a Mouse Model for PKU by Intramuscular Delivery of AAV Expressing PAH with Serotypes 1, 2 or 8 [PDF]

, 2008

openalex   +1 more source

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection

, 2021
Mingwang Long, Yue Pan, Junying Chen, Fan Jia, Han Wang, Daiying Li, Kai Feng, Lingmei Yan, Xiaodan Wang, Xuelei Ning, Lijuan Qiu, Juan Zhang, Qiangming Sun   +12 more
openalex   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

Epidemiologic characteristics of invasive group B streptococcal infections caused by rare serotypes among adults in the United States, 2007-2023. [PDF]

PLOS Glob Public Health
Haldeman S, Prasad N, Metcalf BJ, Taffet A, Schrag SJ, Ratner AJ.   +5 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, EarlyView.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Photo Quiz

Emerging Infectious Diseases
Daniel F.M. Monte, Julia Memrava Cabrera, Fábio P. Sellera   +2 more
doaj   +1 more source

Movement and Survival of Spodoptera litura (Lepidoptera: Noctuidae) Neonate Larvae on Cotton Expressing Bacillus thuringiensis Proteins

Entomologia Experimentalis et Applicata, EarlyView.
Spodoptera litura neonates showed increased movement on Bt‐expressing Bollgard 3 (BG) cotton leaf discs but did not initially avoid it. Survival was higher when larvae could move from BG3 to non‐Bt leaf discs. On whole plants, more larvae dispersed from hatching on BG3 cotton compared to non‐Bt cotton. These findings suggest the larval movement differs
Sharna Holman, Paul Grundy, Helen Spafford, Michael J. Furlong   +3 more
wiley   +1 more source