Results 191 to 200 of about 192,156 (336)

What is driving the resurgence and persistence of vaccine-targeted pneumococcal serotypes?-Serotype 19F as the paradigm. [PDF]

PLoS Pathog
Thindwa D, Carcamo PM, Dagan R, Weinberger DM.   +3 more
europepmc   +1 more source

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Genomic characterization of mobile genetic elements associated with antimicrobial resistance in <i>Streptococcus pneumoniae</i> from Australia. [PDF]

Microb Genom
Sunmonu GT, Coldbeck-Shackley RC, Graham RMA, Leong LE, Ogunniyi AD, Sheppard AE.   +5 more
europepmc   +1 more source

Human Rhinovirus A16 Infection of Mast Cells Promotes T2 and Non‐T2 Immune Responses That Are Modulated by the Airway Epithelium

Allergy, EarlyView.
Ying Lai, Ryan C. Murphy, Matthew Liu, Maciej W. Czarnecki, Dane Grosvenor, Kimberly A. Dill‐McFarland, Adrian M. Piliponsky, Jason S. Debley, Matthew C. Altman, Teal S. Hallstrand   +9 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Molecular Characterization of Southern African Territories 2 (SAT2) Serotype of Foot-and-Mouth Disease Virus from Nigeria in 2017 to 2018

, 2021
Bridget Fomenky, Kate Hole, Hussaini Ularamu, Yiltawe Wungak, David O. Ehizibolo, Michelle Nebroski, Peter Kruczkiewicz, Cody Buchanan, Oliver Lung, Charles Nfon   +9 more
openalex   +1 more source

Development and Validation of Sixplexed Opsonophagocytic Killing Assay for Serotype-Specific Functional Pneumococcal Antibody Measurement. [PDF]

Vaccines (Basel)
Jang AY, Ji HJ, Choi YJ, Nham E, Yoon JG, Choi MJ, Noh JY, Cheong HJ, Seo HS, Song JY.   +9 more
europepmc   +1 more source

Treatment With Valoctocogene Roxaparvovec in a Patient With Severe Hemophilia A Led to Sustained Normal FVIII Levels

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst, Behnaz Pezeshkpoor, Claudia Klein, Thilo Albert, Philipp Lutz, Christian Strassburg, Ulrich Spengler, Georg Goldmann, Johannes Oldenburg   +8 more
wiley   +1 more source

Serotypes and genetic profiles of <i>Bordetella pertussis</i> strains isolated in the city of São Paulo, 2006-2008

, 2012
Daniela Leite, Pamela K. Cassiday, Kathleen M. Tatti, Tânia Mara Ibelli Vaz, M. Lucia Tondella   +4 more
openalex   +2 more sources

Will Extended‐Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At‐Risk Children?

Acta Paediatrica, EarlyView.
Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, IPD Study Group, Emmanuelle Varon   +8 more
wiley   +1 more source