Results 201 to 210 of about 192,156 (336)

Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja, Savita Rangarajan, Will Lester, Bella Madan, Glenn F. Pierce, Emily Symington, Carolyn Millar, Dane Osmond, Mingjin Li, Konstantia‐Maria Chavele   +9 more
wiley   +1 more source

Understanding pathogen, livestock, environment interactions involving bluetongue virus: The PALE-Blu project [PDF]

, 2020
International Livestock Research Institute
core  

Circulating Dengue Serotypes in Sandakan and Kudat districts of Sabah: during 2016 to 2017 [PDF]

, 2019
Timothy Jr Gintarong
openalex  

Genomic characterization of invasive disease-causing <i>Streptococcus pneumoniae</i> in Lebanon, 2003-2025. [PDF]

Microb Genom
Dakroub F, King AC, Akl F, Zaghlout A, Hourani N, Hung H, Barada S, Boutros CF, Ferreira ADS, McGee L, Reslan L, Damaj S, Ghosn N, Matar GM, Araj GF, Abou Fayad A, Bentley SD, Lo SW, Dbaibo GS, For The Lebanese Inter-Hospital Pneumococcal Surveillance Program Investigators.   +19 more
europepmc   +1 more source

Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh, Julia C. Stingl, Marco Stadler, Anja Reichert, Heiner Wedemeyer, Johannes Oldenburg   +5 more
wiley   +1 more source

Optimising cost-effectiveness of freedom from disease surveillance—Bluetongue Virus Serotype 8 as an example

, 2018
Simon R. Rüegg, Sarah Welby, H. Yassin, Yves Van der Stede, Rebekka Nafzger, H.W. Saatkamp, Gertraud Schüpbach‐Regula, Katharina D.C. Stärk   +7 more
openalex   +1 more source

Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensors. [PDF]

PLoS Negl Trop Dis
Nandakumar A, Mishra D, Shendre A, Mendonca E, Nagendra S, Gulyani A, Ramesh A.   +6 more
europepmc   +1 more source

Behavioural and fitness effects of experimental immune activation during incubation in a wild passerine

Ibis, EarlyView.
Incubation is vital for avian embryo development but demands significant parental investment, potentially at the cost of self‐maintenance and immune function. For example, the acute phase response (APR), a systemic reaction against inflammation, infection or tissue injury, can trigger sickness behaviours such as reduced activity and foraging.
Isabel Barreda, Marina García‐del Río, Santiago Merino, Manuel Fuertes‐Recuero, Alejandro Cantarero   +4 more
wiley   +1 more source

Invasive pneumococcal disease surveillance in Canada, 2023. [PDF]

Can Commun Dis Rep
Golden A, Griffith A, Lefebvre B, McGeer A, Tyrrell G, Kus J, Grant J, Minion J, Van Caeseele P, Desnoyers G, Haldane D, Yu Y, Ding X, Steven L, McFadzen J, Zhanel G, Primeau C, Martin I.   +17 more
europepmc   +1 more source

Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Objective To answer the PICoS question ‘in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo‐periodontal lesions, traumatic occlusal forces, prosthesis‐ and tooth‐related factors ...
Inbar Eshkol‐Yogev, Nagore Ambrosio, Cheryl Somani, Elena Figuero, Lior Shapira, Janet Davies   +5 more
wiley   +1 more source