Results 121 to 130 of about 134,892 (370)
Mathematical Modelling to Investigate a Wolbachia Intervention to Reduce Dengue Transmission [PDF]
arXiv, 2017 The introduction of Wolbachia-carrying mosquitoes into the population has recently been proposed as an alternative strategy against dengue. Although laboratory experiments have shown that the Wolbachia bacterium can reduce the levels of dengue virus in mosquitoes, it is also important to assess the performance of Wolbachia in reducing the incidence of ...
arxiv
Serotyping of Streptococcus pneumoniae Based on Capsular Genes Polymorphisms
PLoS ONE, 2013 Streptococcus pneumoniae serotype epidemiology is essential since serotype replacement is a concern when introducing new polysaccharide-conjugate vaccines.
F. Raymond +7 more
semanticscholar +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green +9 more
wiley +1 more source
Mapping of the Influenza-A Hemagglutinin Serotypes Evolution by the ISSCOR Method [PDF]
arXiv, 2013 Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile ...
arxiv
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO [PDF]
arXiv, 2020 An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity ...
arxiv
Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification
Biotechnology and Bioengineering, EarlyView.Peptide‐functionalized affinity resins with high adenovirus binding capacity, recovery, and contaminant removal afford excellent productivity, and reduced impurities in a three‐step purification process. ABSTRACT Adenoviral vectors (AdVs) are gaining prominence in cancer therapy and vaccine development, posing the need for a modern AdV manufacturing ...
Yuxuan Wu +7 more
wiley +1 more source
Dynamics of Dengue with human and vector mobility [PDF]
arXiv, 2014 Dengue is a vector borne disease transmitted to humans by {\it{Aedes Aegypti}} mosquitoes carrying Dengue virus of different serotypes. Primarily an urban epidemic, Dengue exhibits complex spatial and temporal dynamics, influenced by many biological, human and environmental factors.
arxiv
PLoS ONE, 2012 Salmonellosis caused by Salmonella (S.) belongs to the most prevalent food-borne zoonotic diseases throughout the world. Therefore, serotype identification for all culture-confirmed cases of Salmonella infection is important for epidemiological purposes.
S. Braun +6 more
semanticscholar +1 more source
Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement
PLoS Computational Biology, 2014 Pneumococcal conjugate vaccination has proved highly effective in eliminating vaccine-type pneumococcal carriage and disease. However, the potential adverse effects of serotype replacement remain a major concern when implementing routine childhood pneumococcal conjugate vaccination programmes.
Kari Auranen, Markku Nurhonen
openaire +5 more sources
Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses are useful for identifying membrane properties yielding the greatest impact on process performance. In this
Juan J. Romero +6 more
wiley +1 more source