Results 151 to 160 of about 24,818 (268)

Human Skin-Derived Mast Cells Spontaneously Secrete Several Angiogenesis-Related Factors

Frontiers in Immunology, 2019
Mast cells are classically recognized as cells that cause IgE-mediated allergic reactions. However, their ability to store and secrete vascular endothelial growth factor (VEGF) suggests a role in vascular development and tumorigenesis.
Cody McHale, Zahraa Mohammed, Gregorio Gomez   +2 more
doaj   +1 more source

Common prevalence of alanine and glycine in mobile reactive centre loops of serpins and viral fusion peptides: Do prions possess a fusion peptide? [PDF]

, 1994
Isabelle Callebaut, Anne Tasso, Robert Brasseur, Arsène Burny, Daniel Portetelle, Jean Paul Mornon   +5 more
openalex   +1 more source

Miropin, a Novel Bacterial Serpin from the Periodontopathogen Tannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop*

Journal of Biological Chemistry, 2014
Background: Serpins are uncommon in bacteria; little is known about their function. Results: Serpin from T. forsythia (miropin) inhibits a broad array of proteases with divergent specificities. Conclusion: Miropin may allow T.
M. Ksiazek, D. Mizgalska, J. Enghild, C. Scavenius, I. Thøgersen, J. Potempa   +5 more
semanticscholar   +1 more source

Application of the Mass Spectrometry–High‐Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rim Kallel, Rania Zribi, Mahdi Borni, Leila Sellami Hakim, Amina Maalej, Sirine Choura, Mohamed Chamkha, Sami Sayadi, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Kaouthar Zribi, Fathi Safta   +16 more
wiley   +1 more source

Proteolytically cleaved mutant antithrombin‐Hamilton has high stability to denaturation characteristic of wild type inhibitor serpins [PDF]

, 1994
H.T. Wright, Morris A. Blajcliman
openalex   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

BMC Genomics, 2009
Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors.
Micklem Gos, Troxler Laurent, Fullaondo Ane, Garrett Matthew, Gubb David   +4 more
doaj   +1 more source

Effect of the Progesterone-Induced Serpin-Like Proteins of the Sheep Endometrium on Natural-Killer Cell Activity in Sheep and Mice1 [PDF]

, 1993
Wenjun Liu, Peter J. Hansen
openalex   +1 more source

Elevated Circulation Levels of an Anti-angiogenic SERPIN in Patients with Diabetic Microvascular Complications Impairs Wound Healing through Suppression of Wnt Signaling

Journal of Investigative Dermatology, 2014
Wound healing, angiogenesis and hair follicle maintenance are often impaired in the skin of diabetic patients, but the pathogenesis has not been well understood.
J. McBride, A. Jenkins, Xiaochen Liu, Bin Zhang, Kyungwon Lee, William L. Berry, R. Janknecht, Courtney T. Griffin, C. Aston, T. Lyons, J. Tomasek, Jian-xing Ma   +11 more
semanticscholar   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, Volume 12, Issue 8, Page 1595-1607, August 2025.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source