Rhipicephalus microplus serine protease inhibitor family: annotation, expression and functional characterisation assessment [PDF]
Parasites & Vectors, 2015 Background Rhipicephalus (Boophilus) microplus evades the host’s haemostatic system through a complex protein array secreted into tick saliva. Serine protease inhibitors (serpins) conform an important component of saliva which are represented by a large ...
Manuel Rodriguez-Valle +3 more
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Delving into Vertebrate Serpins for Understanding their Evolution [PDF]
Nature Precedings, 2009 The superfamily of serine proteinase inhibitors (serpins) is involved in an array of fundamental biological processes such as blood coagulation, cell differentiation, cell migration, complement activation, embryo implantation, fibrinolysis, angiogenesis,
Abhishek Kumar
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Serpins in the Spotlight: Novel Bioinformatic Insights Into Hyalomma dromedarii Sialotranscriptome [PDF]
Biochemistry Research InternationalTicks pose a significant global threat to human and animal health as vectors of numerous pathogens, including bacteria, viruses, and parasites. Beyond their harmful impact, tick salivary glands contain serine protease inhibitors (serpins) known for their
Hajer Aounallah +4 more
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Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics [PDF]
BMC OphthalmologyBackground Alterations in the constituents of the aqueous humor (AH) are associated with various ocular pathologies, including primary open-angle glaucoma (POAG).
Eliza Williams +11 more
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The roles of serine protease inhibitors in dermatoses [PDF]
Frontiers in GeneticsThe balance between proteases and their inhibitors is essential for maintaining the structural and functional homeostasis of the skin. Numerous studies have shown that serine protease inhibitors are highly expressed in the skin and play diverse roles in ...
Zhenzhen Xiao +5 more
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In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes. [PDF]
PLoS ONE, 2012 Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins ...
Mohammed Asmal +6 more
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Serpins in Tick Physiology and Tick-Host Interaction
Frontiers in Cellular and Infection Microbiology, 2022 Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host.
Adéla Chlastáková +2 more
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Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors [PDF]
Frontiers in ImmunologySerine protease inhibitors (Serpins) are a protein superfamily of protease inhibitors that are thought to play a role in the regulation of inflammation, immunity, tumorigenesis, coagulation, blood pressure and cancer metastasis.
Juanjuan Wang +9 more
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Serpin genes
BMC Plant Biology, 2009 Background The complex responses of plants to DNA damage are incompletely understood and the role of members of the serpin protein family has not been investigated.
Atwell Brian J +2 more
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Ancestry and evolution of a secretory pathway serpin [PDF]
BMC Evolutionary Biology, 2008 Background The serpin (serine protease inhibitor) superfamily constitutes a class of functionally highly diverse proteins usually encompassing several dozens of paralogs in mammals. Though phylogenetic classification of vertebrate serpins into six groups
Ragg Hermann, Kumar Abhishek
doaj +4 more sources