Results 1 to 10 of about 8,727 (225)

Therapeutic SERPINs: Improving on Nature [PDF]

Frontiers in Cardiovascular Medicine, 2021
Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity.
Coen Maas, Steven de Maat
doaj   +2 more sources

Serpins in the Spotlight: Novel Bioinformatic Insights Into Hyalomma dromedarii Sialotranscriptome [PDF]

Biochemistry Research International
Ticks pose a significant global threat to human and animal health as vectors of numerous pathogens, including bacteria, viruses, and parasites. Beyond their harmful impact, tick salivary glands contain serine protease inhibitors (serpins) known for their
Hajer Aounallah, Ahmed Ouni, Fernanda Faria, Ali Bouattour, Youmna M’ghirbi   +4 more
doaj   +2 more sources

Serpins in Tick Physiology and Tick-Host Interaction

Frontiers in Cellular and Infection Microbiology, 2022
Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host.
Muhammad Abbas, Jindrich Chmelař, Michail Kotsyfakis   +2 more
exaly   +3 more sources

Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics [PDF]

BMC Ophthalmology
Background Alterations in the constituents of the aqueous humor (AH) are associated with various ocular pathologies, including primary open-angle glaucoma (POAG).
Eliza Williams, Jeremy Altman, Saleh Ahmed, Garrett Jones, Anshuman Khadanga, Danny Alevy, Kathryn Bollinger, Amy Estes, Steven Safille, Tae Jin Lee, Shruti Sharma, Ashok Sharma   +11 more
doaj   +2 more sources

Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health [PDF]

Gut Microbes
Proteolytic imbalance involving host and microbial serine proteases and their inhibitors (serpins) contributes to intestinal barrier disruption and chronic inflammation in inflammatory bowel disease (IBD).
Meshal Almalki, Camilla R. De Pierri, Tristan Méric, Héla Mkaouar, Donia Slimani, Vincent Mariaule, Sirine Tebassi, Nizar Akermi, Emmanuelle Maguin, Juan Hernandez, Roberto T. Raittz, Moez Rhimi, Francesco Asnicar   +12 more
doaj   +2 more sources

The roles of serine protease inhibitors in dermatoses [PDF]

Frontiers in Genetics
The balance between proteases and their inhibitors is essential for maintaining the structural and functional homeostasis of the skin. Numerous studies have shown that serine protease inhibitors are highly expressed in the skin and play diverse roles in ...
Zhenzhen Xiao, Yue Kang, Yunqian Zhuo, Rui Li, Yingjian Tan, Yingjian Tan   +5 more
doaj   +2 more sources

The Serpin Superfamily in Adipose Tissue Remodeling: Molecular Drivers of Immune–Metabolic Crosstalk and Insulin Sensitivity [PDF]

Biology
Adipose tissue remodeling is a dynamic process essential for metabolic homeostasis, enabling tissue expansion, extracellular matrix (ECM) turnover, angiogenesis, and coordinated immune adaptation. In obesity, however, maladaptive remodeling characterized
Nouran Alwisi, Alaa Abdelhamid, Amna Al-Quradaghi, Maha Talhami, Aldana M. Alkuwari, Nadia Alsharif, Jessica Saliba, Abdullah A. Shaito   +7 more
doaj   +2 more sources

Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors [PDF]

Frontiers in Immunology
Serine protease inhibitors (Serpins) are a protein superfamily of protease inhibitors that are thought to play a role in the regulation of inflammation, immunity, tumorigenesis, coagulation, blood pressure and cancer metastasis.
Juanjuan Wang, Juanjuan Wang, Junqin Li, Junqin Li, Ling Zhou, Ling Zhou, Hui Hou, Hui Hou, Kaiming Zhang, Kaiming Zhang   +9 more
doaj   +2 more sources

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

Frontiers in Cellular and Infection Microbiology, 2017
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Helena Langhansova, Jan Kotal, Jindrich Chmelař   +2 more
exaly   +3 more sources

Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [PDF]

Cell & Bioscience
Background Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
doaj   +2 more sources