Genetic Diversity of Serine Protease Inhibitors in Myxozoan (Cnidaria, Myxozoa) Fish Parasites
Microorganisms, 2020 We studied the genetic variability of serine protease inhibitors (serpins) of Myxozoa, microscopic endoparasites of fish. Myxozoans affect the health of both farmed and wild fish populations, causing diseases and mortalities. Despite their global impact,
Edit Eszterbauer +6 more
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RNAi-mediated knockdown of serine protease inhibitor genes increases the mortality of Plutella xylostella challenged by destruxin A. [PDF]
PLoS ONE, 2014 Destruxin A is a mycotoxin that is secreted by entomopathogenic fungi which has a broad-spectrum insecticidal effect. Previous transcript and protein profiling analysis showed that destruxin A has significant effects on the expression of serine protease ...
Pengfei Han +6 more
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Structural and functional characterization of cleavage and inactivation of human serine protease inhibitors by the bacterial SPATE protease EspPα from enterohemorrhagic E. coli. [PDF]
PLoS ONE, 2014 EspPα and EspI are serine protease autotransporters found in enterohemorrhagic Escherichia coli. They both belong to the SPATE autotransporter family and are believed to contribute to pathogenicity via proteolytic cleavage and inactivation of different ...
André Weiss +2 more
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Frontiers in Immunology, 2021 The moment a very old bacterial pathogen met a young virus from the 80’s defined the beginning of a tragic syndemic for humanity. Such is the case for the causative agent of tuberculosis and the human immunodeficiency virus (HIV).
Elsa Anes +2 more
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Regulation of Neutrophil Serine Proteases by Intracellular Serpins [PDF]
, 2015 Neutrophil granules contain serine proteases that are central components of the antimicrobial weapons of the innate immune system. Neutrophil proteases also contribute to the amplification and resolution of inflammatory responses through defined ...
Benarafa, Charaf
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Deciphering the phylogenetic history of neuroserpin orthologs across metazoans by analysis of synteny and rare genomic characters [PDF]
, 2008 The superfamily of serine proteinase inhibitors (serpins) is involved in wide arrays of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression. The average protein
Hermann Ragg, Abhishek Kumar
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Annals of Medicine, 2023 Objective To explore potential biomarkers indicating endometriosis (EM).Materials and methods A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM.
Xiao-yan Li +5 more
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Serpins: the uncut version [PDF]
Structure, 1994 The structure of active antithrombin, the first active serpin to be solved, sheds new light on the conformational forms of this important class of inhibitor.
E J, Goldsmith, J, Mottonen
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Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes [PDF]
, 2009 Ragg H, Kumar A, Köster K, et al. Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes. BMC Evolutionary Biology.
Hermann Ragg +23 more
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Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
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