“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions [PDF]
Frontiers in Cardiovascular Medicine, 2023 The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a dynamic conformational change to trap and inhibit their target enzymes.
Steven J. Humphreys +2 more
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SERPINs—From Trap to Treatment [PDF]
Frontiers in Medicine, 2019 Excessive enzyme activity often has pathological consequences. This for example is the case in thrombosis and hereditary angioedema, where serine proteases of the coagulation system and kallikrein-kinin system are excessively active. Serine proteases are
Wariya Sanrattana +2 more
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Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins [PDF]
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
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Ancestry and evolution of a secretory pathway serpin [PDF]
BMC Evolutionary Biology, 2008 Background The serpin (serine protease inhibitor) superfamily constitutes a class of functionally highly diverse proteins usually encompassing several dozens of paralogs in mammals. Though phylogenetic classification of vertebrate serpins into six groups
Ragg Hermann, Kumar Abhishek
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Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis [PDF]
Frontiers in Cardiovascular Medicine, 2022 Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis.
Steven P. Grover, Nigel Mackman
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Serine protease inhibitors and human wellbeing interplay: new insights for old friends [PDF]
PeerJ, 2019 Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets.
Héla Mkaouar +8 more
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Molecular Biology and Evolution, 2002 Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure.
James A, Irving +5 more
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Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ∼500 MY [PDF]
PeerJ, 2015 The serpin superfamily is characterized by proteins that fold into a conserved tertiary structure and exploits a sophisticated and irreversible suicide-mechanism of inhibition.
Abhishek Kumar
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Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions
Plants, 2023 Plant serpins are a superfamily of protein inhibitors that have been continuously studied in different species and have great biotechnological potential.
Monaliza Macêdo Ferreira +4 more
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Serpin functions in host-pathogen interactions [PDF]
PeerJ, 2018 Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao +5 more
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