Arginine Inhibits Serpins [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2007 Serine protease inactivators (serpins) are important regulators in biochemistry. Often it is necessary to block the serpin action, that is, to stabilize the sample. The guanidine group of arginine is the ligand for the active center pocket of many serine proteases.
exaly +3 more sources
Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +2 more
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Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [PDF]
Cell & BioscienceBackground Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
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Host cell and viral protease targets of human SERPINs identified by in silico docking [PDF]
The EMBO JournalSerine protease inhibitors (SERPINs) are involved in various physiological processes and diseases, such as inflammation, cancer metastasis, and neurodegeneration.
Joaquin Rodriguez Galvan +9 more
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Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia [PDF]
Reproductive Biology and Endocrinology, 2011 Background SERPINs (serine protease inhibitors) regulate proteases involving fibrinolysis, coagulation, inflammation, cell mobility, cellular differentiation and apoptosis.
Takahashi Toru +3 more
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Immunomodulatory Effects of a Tick Salivary Serpin on Psoriasis-like Inflammation [PDF]
LifePsoriasis is a chronic inflammatory disease with a complex pathogenesis, and it is mainly driven by a dysregulation in immune responses. Therapeutic strategies constantly require novel compounds targeting immune modulation to substitute the current ...
Mohamed Amine Jmel +5 more
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Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini [PDF]
PathogensSerine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang +3 more
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Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages [PDF]
mBioSerine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored.
Esther Nobs +5 more
doaj +2 more sources
Therapeutic SERPINs: Improving on Nature
Frontiers in Cardiovascular Medicine, 2021 Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity.
Coen Maas, Steven de Maat
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“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions
Frontiers in Cardiovascular Medicine, 2023 The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a dynamic conformational change to trap and inhibit their target enzymes.
Steven J. Humphreys +2 more
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