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Serpins in arthropod biology [PDF]
Seminars in Cell & Developmental Biology, 2017 Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest.
David A, Meekins +2 more
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Serpins in rice: protein sequence analysis, phylogeny and gene expression during development
BMC Genomics, 2012 Background Most members of the serpin family of proteins are potent, irreversible inhibitors of specific serine or cysteine proteinases. Inhibitory serpins are distinguished from members of other families of proteinase inhibitors by their metastable ...
Francis Sheila E +4 more
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Necrosis and the Serpin Under't [PDF]
Developmental Cell, 2007 Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Abraham, Mary C., Shaham, Shai
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PLoS ONE, 2021 Here, we studied the expression pattern and putative function of four, previously identified serine protease inhibitors (serpins) of Myxobolus cerebralis, a pathogenic myxozoan species (Cnidaria: Myxozoa) causing whirling disease of salmonid fishes.
Edit Eszterbauer +4 more
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Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]
, 2011 Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle +3 more
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Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2009 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
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G3: Genes, Genomes, Genetics, 2019 The serine protease inhibitor (serpin) gene family is the largest family of protease inhibitors. Serine protease inhibitors have an active, but under-characterized, role in grain development and defense against pathogen attack in cereal crops.
Harriet R. Benbow +2 more
doaj +1 more source
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
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A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
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Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion
Biomolecules, 2020 Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability.
Lina Ma +7 more
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