Results 41 to 50 of about 8,727 (225)
BMC Genomics, 2009 Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors.
Micklem Gos +4 more
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Heparin Blocks the Inhibition of Tissue Kallikrein 1 by Kallistatin through Electrostatic Repulsion
Biomolecules, 2020 Kallistatin, also known as SERPINA4, has been implicated in the regulation of blood pressure and angiogenesis, due to its specific inhibition of tissue kallikrein 1 (KLK1) and/or by its heparin binding ability.
Lina Ma +7 more
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Thrombin inhibition by the serpins [PDF]
Journal of Thrombosis and Haemostasis, 2013 Thrombin is the central protease in the blood coagulation network. It has multiple substrates and cofactors, and it appears that four serpins are responsible for inhibiting the thrombin produced in haemostasis and thrombosis. Structural studies conducted over the last 10 years have resolved how thrombin recognises these serpins with the aid of ...
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Agriculture, 2022 RNA interference (RNAi) induces gene silencing in order to participate in immune-related pathways. Previous studies have shown that the LmSerpin1 gene upregulates the immune responses of Locusta migratoria manilensis, and that the infection of locusts ...
Junya Wang +7 more
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Serpins in theCaenorhabditis elegans genome [PDF]
Proteins: Structure, Function, and Genetics, 1999 Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome ...
J C, Whisstock +4 more
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Parasites & Vectors, 2015 Background Rhipicephalus (Boophilus) microplus evades the host’s haemostatic system through a complex protein array secreted into tick saliva. Serine protease inhibitors (serpins) conform an important component of saliva which are represented by a large ...
Manuel Rodriguez-Valle +3 more
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Misfolding linked mutations of SERPINA1 gene are uncommon in preeclampsia
Archives of Medicine and Health Sciences, 2019 Background: Alpha-1 antitrypsin (A1AT) is a protease inhibitor that plays an important role in regulating oxidative stress in preeclampsia (PE). Recent studies have shown that A1AT is misfolded in PE.
Chandrakala Nagarajappa +2 more
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Nature, 1994 Recent structures of members of the serine proteinase inhibitor families (serpins) continue to emphasize the flexibility of the reactive loop and suggest possible 'active' conformations.
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Advanced Science, EarlyView.SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang +9 more
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, 2008 Serine protease inhibitors (serpins) are a family of proteins that are important in the regulation of several biological processes. This mainly involves the inhibition of serine proteases, although some serpins inhibit a different class of proteases or ...
Bots, Michael, Medema, Jan Paul
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