Results 51 to 60 of about 8,727 (225)

Arginine Inhibits Serpins [PDF]

Clinical and Applied Thrombosis/Hemostasis, 2007
Serine protease inactivators (serpins) are important regulators in biochemistry. Often it is necessary to block the serpin action, that is, to stabilize the sample. The guanidine group of arginine is the ligand for the active center pocket of many serine proteases.
openaire   +2 more sources

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Phylogenomics of vertebrate serpins [PDF]

, 2010
Kumar A. Phylogenomics of vertebrate serpins. Bielefeld (Germany): Bielefeld University; 2010.The serpins constitute a superfamily of proteins that fold into a conserved tertiary structure and employ a sophisticated, irreversible suicide-mechanism of ...
Kumar, Abhishek
core  

Investigated tsetse midgut serpins.

, 2015
Four putative serpins were initially identified from a tsetse midgut EST library. Subsequent sequencing and annotation of the genome has now assigned these serpins with GMOY IDs in the Invertebrate Vectors of Human Pathogens database, VectorBase (https://
Cher-Pheng Ooi (682424), Lee R. Haines (42456), Michael J. Lehane (197355), Daniel M. Southern (682425), Alvaro Acosta-Serrano (213459)   +4 more
core   +1 more source

Thrombin Inhibition by Serpins Disrupts Exosite II [PDF]

, 2010
Thrombin uses three principal sites, the active site, exosite I, and exosite II, for recognition of its many cofactors and substrates. It is synthesized in the zymogen form, prothrombin, and its activation at the end of the blood coagulation cascade ...
Daniel J.D. Johnson, DE FILIPPIS, VINCENZO, POZZI, NICOLA, Ty E. Adams, Nicola Pozzi, D. J. D. JOHNSON, Vincenzo De Filippis, J. A. HUNTINGTON, Wei Li, W. LI, T. E. ADAMS, James A. Huntington   +11 more
core   +1 more source

Crystallographic analysis of serpins and bacterial response regulator.

, 2002
Crystallographic analysis of serpins and bacterial response ...
Miljan. Simonovic (7986422)
core   +6 more sources

Ixodes scapularis tick

ser

ine proteinase

in

hibitor (serpin) gene family; annotation and transcriptional analysis

BMC Genomics, 2009
Background Serine proteinase inhibitors (Serpins) are a large superfamily of structurally related, but functionally diverse proteins that control essential proteolytic pathways in most branches of life.
Chalaire Katelyn C, Khumthong Rabuesak, Mulenga Albert   +2 more
doaj   +1 more source

Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant

Frontiers in Cardiovascular Medicine, 2021
Alpha-1 antitrypsin (AAT, also known as alpha-1 proteinase inhibitor or SERPINA1) is the most abundant member of the serpin superfamily found in human plasma.
Mostafa Hamada, Varsha Bhakta, Sara N. Andres, William P. Sheffield, William P. Sheffield   +4 more
doaj   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Serpins from wheat grain [PDF]

, 1994
Wheat serpin genes have been identified by Southern blot hybridization with three distinct barley protein Z probes. Immunoblot analysis with a monoclonal antibody towards barley protein Z confirmed expression of related Mr ~ 40 kDa proteins in wheat ...
Rasmussen, Søren K., Jørn Hejgaard, Hejgaard, Jørn, Søren K. Rasmussen, Søren E. Bjørn, Rosenkrands, Ida, Bjørn, S.E., Rosenkrands, I., Hejgaard, J., Bjørn, Søren E., Ida Rosenkrands, Rasmussen, Søren Kjærsgård   +11 more
core   +1 more source