Results 31 to 40 of about 8,727 (225)
A curated structural dataset of peptide-protein complexes reveals biases in existing datasets and principles of peptide binding. [PDF]
Protein SciAbstract Peptide–protein interactions are fundamental to many biological processes, and peptide design is gaining interest due to its therapeutic potential. This has led to the emergence of various structural databases, such as PepBDB and Peptipedia, that classify peptides as polypeptides with fewer than 50 amino acids. These databases provide valuable
Hamdani R, Delgado J, Serrano L.
europepmc +2 more sources
Interaction of subtilisins with serpins [PDF]
Protein Science, 1996 AbstractSerpins are well‐characterized inhibitors of the chymotrypsin family serine proteinases. We have investigated the interaction of two serpins with members of the subtilisin family, proteinases that possess a similar catalytic mechanism to the chymotrypsins, but a totally different scaffold.
T, Komiyama +3 more
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Serpins in rice: protein sequence analysis, phylogeny and gene expression during development
BMC Genomics, 2012 Background Most members of the serpin family of proteins are potent, irreversible inhibitors of specific serine or cysteine proteinases. Inhibitory serpins are distinguished from members of other families of proteinase inhibitors by their metastable ...
Francis Sheila E +4 more
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Serpins in arthropod biology [PDF]
Seminars in Cell & Developmental Biology, 2017 Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest.
David A, Meekins +2 more
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Necrosis and the Serpin Under't [PDF]
Developmental Cell, 2007 Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Abraham, Mary C., Shaham, Shai
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G3: Genes, Genomes, Genetics, 2019 The serine protease inhibitor (serpin) gene family is the largest family of protease inhibitors. Serine protease inhibitors have an active, but under-characterized, role in grain development and defense against pathogen attack in cereal crops.
Harriet R. Benbow +2 more
doaj +1 more source
Control of granzymes by serpins [PDF]
Cell Death & Differentiation, 2009 Although proteolysis mediated by granzymes has an important role in the immune response to infection or tumours, unrestrained granzyme activity may damage normal cells. In this review, we discuss the role of serpins within the immune system, as specific regulators of granzymes. The well-characterised human granzyme B-SERPINB9 interaction highlights the
D, Kaiserman, P I, Bird
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Identification and in-silico characterization of Serpin genes in legumes genomes
The Indian Journal of Agricultural Sciences, 2020 Serine protease inhibitors (serpins) are a unique family of protease inhibitor containing mobile reactive center loop. The availability of genome sequences of pigeonpea, soybean, commanbean, cowpea, mungbean and adzuki bean provided an opportunity to ...
PAWAN S MAINKAR +5 more
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PLoS ONE, 2021 Here, we studied the expression pattern and putative function of four, previously identified serine protease inhibitors (serpins) of Myxobolus cerebralis, a pathogenic myxozoan species (Cnidaria: Myxozoa) causing whirling disease of salmonid fishes.
Edit Eszterbauer +4 more
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Egg serpins: The chicken and/or the egg dilemma [PDF]
, 2016 Twenty-seven serpins belonging to clade A, B, C, D, E, F, G, H and I serpins are currently referenced in chicken genome databases. Phylogenetic analysis of chicken serpins revealed that ovalbumin (Serpinb14) and its paralogs ovalbumin-related protein Y ...
Dombre, Clara +6 more
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