Results 181 to 190 of about 23,239 (235)

Comprehensive Proteomic Profiling Reveals Dysregulation of Angiogenesis and Inflammatory Pathways in the Brains of SIRT3 Knockout Mice. [PDF]

Brain Sci
He Q, Khan S, Wang L, Ibeanu GC, Li PA.
europepmc   +1 more source

Pancreatic Digestive Enzyme Dispersion into Human Organs Outside the Gastrointestinal Tract. [PDF]

J Proteome Res
Chavan R, Schmid-Schönbein GW.
europepmc   +1 more source

SLPI and CXCL10 in non-obese patients, and Serpin E1 in obese patients as AKI biomarkers after cardiac surgery

Brown N, Pan H, Sullo N, Eagle-Hemming B, Tomkova K, Joel-David L, Kumar T, Aujla H, Goodall AH, Murphy GJ, Woźniak MJ, Yang B.   +11 more
europepmc   +1 more source

Early pregnancy biomarkers of inflammation and metabolic regulation in polycystic ovary syndrome.

J Clin Endocrinol Metab
Alesi S, Mason T, Ellery SJ, Rassie K, Neven ACH, Belsti Y, Jona E, O'Reilly S, Simmons D, Teede H, Mousa A, IMPACT DIABETES B2B&ME, TOBOGM Study Groups.   +12 more
europepmc   +1 more source

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Serpin crystal structure and serpin polymer structure

Archives of Biochemistry and Biophysics, 2006
Serpins are a family of structurally homologous proteins having metastable native structures. As a result, a serpin variant destabilized by mutation(s) has a tendency to undergo conformational changes leading to inactive forms, e.g., the latent form and polymer. Serpin polymers are involved in a number of conformational diseases.
Ewa Marszal
exaly   +3 more sources

Identification of Serpin Determinants of Specificity and Selectivity for Furin Inhibition through Studies of α1PDX (α1-Protease Inhibitor Portland)-Serpin B8 and Furin Active-site Loop Chimeras [PDF]

Journal of Biological Chemistry, 2013
α1-Protease inhibitor Portland (α1PDX) is an engineered serpin family inhibitor of the proprotein convertase (PC), furin, that exhibits high specificity but limited selectivity for inhibiting furin over other PC family proteases.
Steven Olson, Gonzalo Izaguirre
exaly   +7 more sources

Serpin mutagenesis

Methods, 2004
Mutagenesis represents a powerful methodology for the analysis of protein structural and functional relationships and dissection of complex protein-protein interactions. The suicide substrate-like inhibitory mechanism of the proteins of the serpin superfamily offers unique challenges for the design of mutagenesis studies.
Toni M, Antalis, Daniel A, Lawrence
openaire   +2 more sources

The structure of active serpin 1K from Manduca sexta [PDF]

Structure, 1999
Background: The reactive center loops (RCL) of serpins undergo large conformational changes triggered by the interaction with their target protease. Available crystallographic data suggest that the serpin RCL is polymorphic, but the relevance of the ...
Elizabeth Goldsmith, Michael Kanost, Haobo Jiang   +2 more
exaly   +2 more sources

Crystallography of Serpins and Serpin Complexes

2011
The serpin superfamily of protease inhibitors undergoes a remarkable conformational change to inhibit target proteases. To date, over 80 different serpin crystal structures have been determined. These data reveal that the serpin monomer can adopt five different conformations (native, partially inserted native, δ-form, latent, and cleaved).
M A, Dunstone, James C, Whisstock
openaire   +2 more sources