Results 241 to 250 of about 24,818 (268)
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2015
The serpins are a family of structurally conserved protease inhibitors found mainly in the animal and plant kingdoms. This chapter will focus on the evolution of plant serpins brought to light by mining of the growing number of whole plant genomes. Our analysis shows remarkable diversification of plant serpins as compared to those in animals. Indeed, a
Robert Fluhr +2 more
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The serpins are a family of structurally conserved protease inhibitors found mainly in the animal and plant kingdoms. This chapter will focus on the evolution of plant serpins brought to light by mining of the growing number of whole plant genomes. Our analysis shows remarkable diversification of plant serpins as compared to those in animals. Indeed, a
Robert Fluhr +2 more
openaire +2 more sources
Biochemistry, 2017
The Myxomavirus-derived protein Serp-1 has potent anti-inflammatory activity in models of vasculitis, lupus, viral sepsis, and transplant. Serp-1 has also been tested successfully in a Phase IIa clinical trial in unstable angina, representing a "first-in-
B. Mahon +13 more
semanticscholar +1 more source
The Myxomavirus-derived protein Serp-1 has potent anti-inflammatory activity in models of vasculitis, lupus, viral sepsis, and transplant. Serp-1 has also been tested successfully in a Phase IIa clinical trial in unstable angina, representing a "first-in-
B. Mahon +13 more
semanticscholar +1 more source
Structural insights into serpin—protease complexes reveal the inhibitory mechanism of serpins [PDF]
Nature Structural & Molecular Biology, 1997 Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins.
Jan Karolin +5 more
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Serpin–Glycosaminoglycan Interactions
2011Serpins (serine protease inhibitors) have traditionally been grouped together based on structural homology. They share common structural features of primary sequence, but not all serpins require binding to cofactors in order to achieve maximal protease inhibition. In order to obtain physiologically relevant rates of inhibition of target proteases, some
Chantelle M. Rein +2 more
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Serpins and the Complement System
2011C1-inhibitor (serpin G1) is a 105 kDa inhibitor which functions as a major antiinflammatory protein in the body. It has its effects via inhibition of the proteases of the complement system and contact system of coagulation, as well as several direct effects mediated by its unique highly glycosylated N-terminal domain.
Péter Závodszky +6 more
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Maspin: A Tumor Suppressing Serpin
1996Maspin, a serpin found in mammary epithelial cells, has been shown to have tumor suppressor activity. The gene is expressed in normal human mammary epithelial cells but down-regulated in invasive breast carcinomas. Similar patterns of expression at the RNA and protein levels are seen by Northern analysis with cells grown in culture and by ...
Mary J.C. Hendrix +3 more
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Evolutionary history of the uterine serpins
Journal of Experimental Zoology, 2000A bioinformatics analysis was conducted on the four members of the uterine serpin (US) family of serpins. Evolutionary analysis of the protein sequences and 86 homologous serpins by maximum parsimony and distance methods indicated that the uterine serpins proteins form a clade distinct from other serpins.
Steven A. Benner +4 more
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Cardiovascular & Hematological Agents in Medicinal Chemistry, 2015
Fibrinolysis is the ultimate outcome of a cascade of enzymatic reactions in which serine proteases such as plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) are the key players.
Rami A. Al‐Horani
semanticscholar +1 more source
Fibrinolysis is the ultimate outcome of a cascade of enzymatic reactions in which serine proteases such as plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) are the key players.
Rami A. Al‐Horani
semanticscholar +1 more source
The FEBS Journal, 2005
Much of the basic biochemistry of antiplasmin was described more than 20 years ago and yet it remains an enigmatic member of the serine protease inhibitor (serpin) family. It possesses all of the characteristics of other inhibitory serpins but in addition it has unique N‐ and C‐terminal extensions which significantly modify its activities.
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Much of the basic biochemistry of antiplasmin was described more than 20 years ago and yet it remains an enigmatic member of the serine protease inhibitor (serpin) family. It possesses all of the characteristics of other inhibitory serpins but in addition it has unique N‐ and C‐terminal extensions which significantly modify its activities.
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Science Translational Medicine, 2014
Serpins help breast and lung cancer cells metastasize to the brain by annulling stromal defenses and co-opting capillaries.
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Serpins help breast and lung cancer cells metastasize to the brain by annulling stromal defenses and co-opting capillaries.
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