Results 251 to 260 of about 24,818 (268)
Some of the next articles are maybe not open access.
Serpins in plants and green algae
Functional & Integrative Genomics, 2007Control of proteolysis is important for plant growth, development, responses to stress, and defence against insects and pathogens. Members of the serpin protein family are likely to play a critical role in this control through irreversible inhibition of endogenous and exogenous target proteinases. Serpins have been found in diverse species of the plant
Jørn Hejgaard, Thomas H. Roberts
openaire +3 more sources
2011
Members of the serpin superfamily of proteins have been found in all living organisms, although rarely in bacteria or fungi. They have been extensively studied in mammals, where many rapid physiological responses are regulated by inhibitory serpins. In addition to the inhibitory serpins, a large group of noninhibitory proteins with a conserved serpin ...
Jean Marc Reichhart +2 more
openaire +2 more sources
Members of the serpin superfamily of proteins have been found in all living organisms, although rarely in bacteria or fungi. They have been extensively studied in mammals, where many rapid physiological responses are regulated by inhibitory serpins. In addition to the inhibitory serpins, a large group of noninhibitory proteins with a conserved serpin ...
Jean Marc Reichhart +2 more
openaire +2 more sources
Serpins in Caenorhabditis elegans
2015C. elegans is an extremely powerful model organism to study gene function and biology. The nematodes’ genetic tractability and high degree of genetic similarity with humans make it ideal to study the biologic role of serpins. The endogenous C. elegans serpins are most similar to the human clade B or intracellular serpin family and have a predominantly ...
Cliff J. Luke +6 more
openaire +2 more sources
Science's STKE, 2007
Biologically active proteases are held in check in part by a family of peptidase inhibitors known as serpins. Most serpins are secreted proteins, but some are intracellular proteins implicated in regulating lysosomal proteases. Knockout mice have failed to reveal the biological roles of these inhibitors, though--possibly because mice have ...
openaire +2 more sources
Biologically active proteases are held in check in part by a family of peptidase inhibitors known as serpins. Most serpins are secreted proteins, but some are intracellular proteins implicated in regulating lysosomal proteases. Knockout mice have failed to reveal the biological roles of these inhibitors, though--possibly because mice have ...
openaire +2 more sources
Inflammation and Noninhibitor Serpins
1997Pigment epithelium-derived factor (PEDF) is a member of the serpin family with neurotrophic activity. However, PEDF belongs to the non-inhibitory subgroup of serpins and its neurotrophic activity does not require inhibition of proteases. PEDF induces neuronal survival on cerebellar granule cell neurons and neurite-outgrowth on retinoblastoma cells ...
Elena Alberdi, S. Patricia Becerra
openaire +2 more sources
Serpins: Development for Therapeutic Applications
2018Serine protease inhibitors, or serpins, function as central regulators for many vital processes in the mammalian body, maintaining homeostasis for clot formation and breakdown, immune responses, lung function, and hormone or central nervous system activity, among many others.
Liqiang Zhang +4 more
openaire +2 more sources
Serpins and Regulation of Cell Death
1998Proteolysis is a key feature of programmed cell death. Extracellular proteinases can activate cell surface receptors which trigger apoptosis, and the effector machinery requires the activation and activity of numerous intracellular proteinases (primarily caspases).
openaire +3 more sources
Biology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone.
Seminars in Cell and Developmental Biology, 2017S. Ito, K. Nagata
semanticscholar +1 more source
Genetic engineering and the serpins
BioEssays, 1988Robin W. Carrell, D. Ross Boswell
openaire +3 more sources