Role of SERPINA1 in the tumor immune microenvironment of breast cancer and construction of a prognostic model [PDF]
Discover OncologyBackground Breast cancer is a common malignancy where the immune system plays a key role in disease progression and treatment response. SERPINA1 is an immune-related gene, but its function in breast cancer remains unclear.
Xiaolin Xia +4 more
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SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment [PDF]
Scientific ReportsThis study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed.
Chuqi Lei +7 more
doaj +2 more sources
SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma [PDF]
International Dental JournalObjective: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined.
Jingkun Zhang +4 more
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Do LRG1–SERPINA1 Interactions Modulate Fibrotic and Inflammatory Signatures in Rheumatoid Arthritis? A Proteomic and In Silico Investigation [PDF]
PathophysiologyBackground: Rheumatoid arthritis (RA) is a systemic, pro-inflammatory, autoimmune disease that mainly affects the joints in a symmetrical manner. Differential proteomic profiling through Sequential Window Acquisition of all Theoretical Fragment Ion Mass ...
Talib Hussain +2 more
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SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis [PDF]
Discover OncologyBackground The immune response can be modulated by autophagy to alter tumor growth. SERPINA1 is not only an autophagy-related protein but also a serine protease inhibitor with the potential for immunotherapy and targeted drug therapy.
Chen Fu +3 more
doaj +2 more sources
Functional and clinical significance of novel SERPINA1 variants on alpha-1 antitrypsin deficiency [PDF]
Respiratory ResearchBackground Mutations in the SERPINA1 gene can result in alpha-1 antitrypsin deficiency (AATD), which may be associated with lung or liver injury. Although the S and Z alleles account for over 95% of cases of AATD, a wide variety of rare variants have ...
Nerea Matamala +22 more
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Characterization of a novel SERPINA1 variant carrying two missense mutations: molecular mechanisms and functional impact [PDF]
Orphanet Journal of Rare DiseasesAlpha 1-Antitrypsin Deficiency (AATD) is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes the Alpha 1-Antitrypsin (AAT) protein.
Celine Leon +25 more
doaj +2 more sources
Bioinformatic analysis of serpina1 expression in papillary thyroid carcinoma and its potential association with Hashimoto's thyroiditis [PDF]
Discover OncologyPurpose Previous studies have suggested that SERPINA1 may promote a better prognosis in papillary thyroid carcinoma (PTC) along with Hashimoto's thyroiditis (HT).
Xiuyuan Du, Wanjun Chen
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SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway [PDF]
Clinical EpigeneticsMost thyroid nodules can be diagnosed preoperatively by ultrasonography and fine-needle aspiration biopsy. However, accurately differentiating between benign nodules or indolent thyroid tumors and aggressive thyroid cancers remains a significant clinical
Junjie Li +7 more
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Genetic drivers of liver cirrhosis: The role of SERPINA1 and PNPLA3 variants in disease onset and progression. [PDF]
PLoS ONESERPINA1 Z and PNPLA3 G alleles are the most potent genetic risk modifiers in chronic liver disease (CLD) progression. We aimed to test the impact of concomitant carriage of these variants on the progression of CLDs of various aetiology.
Mikolas Holinka +13 more
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