Results 1 to 10 of about 11,907 (228)

SERPINA1 gene regulates the tumorigenesis and progression of breast cancer through PI3K/AKT signaling pathway and tumor immune microenvironment [PDF]

Scientific Reports
This study aims to reveal the influence of SERPINA1 gene on the development, prognosis evaluation and immune environment changes of breast cancer. Cell lines with differential SERPINA1 expression were constructed.
Chuqi Lei, Wei Lu, Yuan Li, Huaiyu yang, Ke Zhang, Nianchang Wang, Lixue Xuan, Changyuan Guo   +7 more
doaj   +3 more sources

SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis [PDF]

Discover Oncology
Background The immune response can be modulated by autophagy to alter tumor growth. SERPINA1 is not only an autophagy-related protein but also a serine protease inhibitor with the potential for immunotherapy and targeted drug therapy.
Chen Fu, Yanyun Hu, Lei Yang, Weifeng Sun   +3 more
doaj   +3 more sources

Bioinformatic analysis of serpina1 expression in papillary thyroid carcinoma and its potential association with Hashimoto's thyroiditis [PDF]

Discover Oncology
Purpose Previous studies have suggested that SERPINA1 may promote a better prognosis in papillary thyroid carcinoma (PTC) along with Hashimoto's thyroiditis (HT).
Xiuyuan Du, Wanjun Chen
doaj   +3 more sources

Characterization of a novel SERPINA1 variant carrying two missense mutations: molecular mechanisms and functional impact [PDF]

Orphanet Journal of Rare Diseases
Alpha 1-Antitrypsin Deficiency (AATD) is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes the Alpha 1-Antitrypsin (AAT) protein.
Celine Leon, Marie-Françoise Odou, Bertrand Roquelaure, Louis Lebreton, Mathias Ruiz, Carolin Victoria Schneider, Celine Renoux, Aurélie Evrard, Malika Balduyck, Magali Dechomet, Christine Lombard, Mathilde Butori-Pepino, Kai Markus Schneider, Victor Marin, Sylvaine di-Tomasso, Cyril Dourthe, Jean-William Dupuy, Anne-Aurélie Raymond, Sophie Collardeau-Frachon, Aurélie Haffner, Radia Fritih, Emmanuelle Goubert, Vanna Geromel, Philippe Joly, Alexandre Fabre, Marion Bouchecareilh   +25 more
doaj   +3 more sources

SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway [PDF]

Clinical Epigenetics
Most thyroid nodules can be diagnosed preoperatively by ultrasonography and fine-needle aspiration biopsy. However, accurately differentiating between benign nodules or indolent thyroid tumors and aggressive thyroid cancers remains a significant clinical
Junjie Li, Haixia Huang, Yifei Yin, Yizhu Mao, Mengxia Li, Hong Li, Chenxia Jiang, Rongxi Yang   +7 more
doaj   +3 more sources

Genetic drivers of liver cirrhosis: The role of SERPINA1 and PNPLA3 variants in disease onset and progression. [PDF]

PLoS ONE
SERPINA1 Z and PNPLA3 G alleles are the most potent genetic risk modifiers in chronic liver disease (CLD) progression. We aimed to test the impact of concomitant carriage of these variants on the progression of CLDs of various aetiology.
Mikolas Holinka, Sona Frankova, Svetlana Adamcova Selcanova, Lubomir Skladany, Ondrej Fabian, Martin Kveton, Dusan Merta, Vera Adamkova, Jaroslav A Hubacek, Veronika Pitova, Sarka Vesela, Tomas Hucl, Milan Jirsa, Jan Sperl   +13 more
doaj   +3 more sources

Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression [PDF]

Scientific Reports
Alternative polyadenylation results in different 3’ isoforms of messenger RNA (mRNA) transcripts. Alternative polyadenylation in the 3’ untranslated region (3’UTR) can alter RNA localization, stability and translational efficiency.
F. N. U. Jiamutai, Abigail Hatfield, Austin Herbert, Debarati Majumdar, Vijay Shankar, Lela Lackey   +5 more
doaj   +3 more sources

CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling

Cell Death Discovery
Colorectal cancer (CRC) is a highly malignant carcinoma associated with poor prognosis, and metastasis is one of the most common causes of death in CRC. Serpin Family A Member 1 (SERPINA1) is a serine protease inhibitor from the Serpin family.
Yiming Ma, Ying Chen, Lei Zhan, Qian Dong, Yuanhe Wang, Xiaoyan Li, Lian He, Jingdong Zhang   +7 more
doaj   +2 more sources

SERPINA1 as a Shared Biomarker in Periodontitis and Oral Squamous Cell Carcinoma [PDF]

International Dental Journal
Objective: Periodontitis (PD) and oral squamous cell carcinoma (OSCC) frequently co‑occur in clinical populations. However, shared molecular determinants that could support risk assessment across diseases remain insufficiently defined.
Jingkun Zhang, Guangwei Chen, Qi Wang, Yali Chi, Guoxu Han   +4 more
doaj   +2 more sources

SERPINA1 drives TACE resistance in hepatocellular carcinoma by competitively binding ITGB3 to block ITCH-mediated ubiquitination and degradation. [PDF]

Cell Oncol (Dordr)
Transarterial chemoembolization (TACE) is the first-line treatment for intermediate-to-advanced hepatocellular carcinoma (HCC), but post-TACE resistance remains a major clinical challenge.
Zhang L, Bai X, Du M, Dou W, Xie Z, Liu J, Hou Y.   +6 more
europepmc   +2 more sources