Results 31 to 40 of about 10,821 (196)

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency. [PDF]

, 2011
The serine proteinase inhibitor α-1 anti-trypsin (AAT) provides an antiprotease protective screen throughout the body. Mutations in the AAT gene (SERPINA1) that lead to deficiency in AAT are associated with chronic obstructive pulmonary diseases.
Greene, Catherine M, Hassan, Tidi, McElvaney, Noel G, Molloy, Kevin   +3 more
core   +2 more sources

SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

Frontiers in Cell and Developmental Biology, 2020
SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy.
John Charles Rotondo, Lucia Oton-Gonzalez, Rita Selvatici, Paola Rizzo, Rita Pavasini, Rita Pavasini, Gianluca Calogero Campo, Gianluca Calogero Campo, Carmen Lanzillotti, Chiara Mazziotta, Monica De Mattei, Mauro Tognon, Fernanda Martini   +12 more
doaj   +1 more source

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading cause of LBP.
Xiao Yang, Yang Lu, Hang Zhou, Hai-Tao Jiang, Lei Chu   +4 more
doaj   +1 more source

Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. [PDF]

, 2018
Engineering of the Cpf1 crRNA has the potential to enhance its gene editing efficiency and non-viral delivery to cells. Here, we demonstrate that extending the length of its crRNA at the 5 end can enhance the gene editing efficiency of Cpf1 both in cells
Chong, Anthony, Chu, Hunghao, Fellmann, Christof, Jiang, Fuguo, Lee, Kunwoo, Liu, Hui, Mackley, Vanessa, Murthy, Niren, Park, Hyo, Rao, Anirudh, Wu, Joann   +10 more
core   +2 more sources

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Global 5′-UTR RNA structure regulates translation of a SERPINA1 mRNA

Nucleic Acids Research, 2022
Abstract SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in the 5′-untranslated region (5′-UTR) are associated with COPD.
Philip J Grayeski, Chase A Weidmann, Jayashree Kumar, Lela Lackey, Anthony M Mustoe, Steven Busan, Alain Laederach, Kevin M Weeks   +7 more
openaire   +2 more sources

SERPINA1 Peptides in Urine as A Potential Marker of Preeclampsia Severity [PDF]

International Journal of Molecular Sciences, 2020
Preeclampsia (PE) is a multisystem disorder associated with pregnancy and its frequency varies from 5 to 20 percent of pregnancies. Although a number of preeclampsia studies have been carried out, there is no consensus about disease etiology and pathogenesis so far. Peptides of SERPINA1 (α1-antitrypsin) in urine remain one of the most promising peptide
Natalia Starodubtseva, Natalia Nizyaeva, Oleg Baev, Anna Bugrova, Masara Gapaeva, Kamilla Muminova, Alexey Kononikhin, Vladimir Frankevich, Eugene Nikolaev, Gennady Sukhikh   +9 more
openaire   +2 more sources

Identification of SERPINA1 promoting better prognosis in papillary thyroid carcinoma along with Hashimoto’s thyroiditis through WGCNA analysis

Frontiers in Endocrinology, 2023
BackgroundHashimoto’s thyroiditis (HT) is an autoimmune thyroid disease. Papillary thyroid carcinoma (PTC) is the most common endocrine cancer. In recent years the rate of coexistence between PTC and HT has increased but the relationship between them ...
Yihan Zhang, Xin Xie, Hong Zhou, Bingxin Li, Li Ding, Zhaogen Cai, Huaidong Song, Shuangxia Zhao, Huanbai Xu   +8 more
doaj   +1 more source

Tissue-specific gene silencing monitored in circulating RNA [PDF]

, 2013
Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene ...
Bumcrot, David A., Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W. Y., Sehgal, Alfica   +4 more
core   +1 more source

Hepatocyte-like cells reveal novel role of SERPINA1 in transthyretin amyloidosis [PDF]

Journal of Cell Science, 2018
ABSTRACT Transthyretin (TTR)-related familial amyloid polyneuropathy (ATTR) results from aggregation and extracellular disposition of misfolded TTR mutants. Growing evidence suggests the importance of hepatic chaperones for the modulation of pathogenesis.
Christoph Niemietz, Lutz Fleischhauer, Vanessa Sandfort, Sarah Guttmann, Andree Zibert, Hartmut H.-J. Schmidt   +5 more
openaire   +2 more sources