Results 31 to 40 of about 11,907 (228)

Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer’s Disease

International Journal of Molecular Sciences, 2022
SerpinA1 (α1-antitrypsin) is a soluble glycoprotein, the cerebrospinal fluid (CSF) isoforms of which showed disease-specific changes in neurodegenerative disorders that are still unexplored in Alz-heimer’s disease (AD). By means of capillary isoelectric focusing immunoassay, we investigated six serpinA1 isoforms in CSF samples of controls (n = 29), AD ...
Lorenzo Barba, Steffen Halbgebauer, Federico Paolini Paoletti, Giovanni Bellomo, Samir Abu-Rumeileh, Petra Steinacker, Federico Massa, Lucilla Parnetti, Markus Otto   +8 more
openaire   +2 more sources

Key inflammatory pathway activations in the MCI stage of Alzheimer's disease [PDF]

, 2019
OBJECTIVE: To determine the key inflammatory pathways that are activated in the peripheral and CNS compartments at the mild cognitive impairment (MCI) stage of Alzheimer's disease (AD).
Bekris, Lynn M., Bena, James, Chance, Mark, Lamb, Bruce T., Leverenz, James B., Maxwell, Sean, Pillai, Jagan A., Rao, Stephen M.   +7 more
core   +2 more sources

Genetic diagnosis of α1-antitrypsin deficiency using DNA from buccal swab and serum samples [PDF]

, 2017
Background: α1-Antitrypsin deficiency (AATD) is associated with a high risk of developing lung and liver disease. Despite being one of the most common hereditary disorders worldwide, AATD remains under-diagnosed and prolonged delays in diagnosis are ...
Barrecheguren, Miriam, Belmonte, Irene, Esquinas López, Cristina, Miravitlles Fernández, Marc, Rodriguez-Frias, Francisco, Rodríguez, Esther   +5 more
core   +1 more source

SerpinA1 levels in amyotrophic lateral sclerosis patients: An exploratory study

European Journal of Neurology, 2023
AbstractBackgroundSerpinA1, a serine protease inhibitor, is involved in the modulation of microglial‐mediated inflammation in neurodegenerative diseases. We explored SerpinA1 levels in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients to understand its potential role in the pathogenesis of the disease.MethodsSerpinA1 ...
Martinelli, Ilaria, Zucchi, Elisabetta, Simonini, Cecilia, Gianferrari, Giulia, Bedin, Roberta, Biral, Chiara, Ghezzi, Andrea, Fini, Nicola, Carra, Serena, Mandrioli, Jessica   +9 more
openaire   +2 more sources

SERPINA1 Gene Promoter Is Differentially Methylated in Peripheral Blood Mononuclear Cells of Pregnant Women

Frontiers in Cell and Developmental Biology, 2020
SERine Protein INhibitor-A1 (SERPINA1) is an inducible blood cell gene coding for alpha1-antitrypsin (AAT), a plasma protease inhibitor whose circulating levels are raised during inflammation, infection and advanced pregnancy.
John Charles Rotondo, Lucia Oton-Gonzalez, Rita Selvatici, Paola Rizzo, Rita Pavasini, Rita Pavasini, Gianluca Calogero Campo, Gianluca Calogero Campo, Carmen Lanzillotti, Chiara Mazziotta, Monica De Mattei, Mauro Tognon, Fernanda Martini   +12 more
doaj   +1 more source

The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency. [PDF]

, 2011
The serine proteinase inhibitor α-1 anti-trypsin (AAT) provides an antiprotease protective screen throughout the body. Mutations in the AAT gene (SERPINA1) that lead to deficiency in AAT are associated with chronic obstructive pulmonary diseases.
Greene, Catherine M, Hassan, Tidi, McElvaney, Noel G, Molloy, Kevin   +3 more
core   +2 more sources

α1-Antitrypsin deficiency. [PDF]

, 2016
α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes underdiagnosed or misdiagnosed as asthma, chronic obstructive pulmonary disease ...
Brantly, Mark L, Ferrarotti, Ilaria, Greene, Catherine M, Lomas, David A, Marciniak, Stefan J, McElvaney, Noel G, Stoller, James K, Teckman, Jeffrey   +7 more
core   +2 more sources

Development of a MALDI MS-based platform for early detection of acute kidney injury [PDF]

, 2016
Purpose: Septic acute kidney injury (AKI) is associated with poor outcome. This can partly be attributed to delayed diagnosis and incomplete understanding of the underlying pathophysiology.
Albalat, Albrethsen, Albrethsen, Ali, Amdur, Bagshaw, Basile, Bellomo, Bouchard, Breen, Chawla, Chertow, Coca, Coca, Davidman, Doi, Endre, Gaieski, Garner, Geus, Giebel, Glorieux, Goldstein, Good, Greenwel, Ho, Ishani, Iskander, Kim, Liu, Metzger, Molin, Okada, Schaub, Schrier, Theodorescu, Vanmassenhove, Vincent, Wald, Wan, Wiedemann, Zarjou, Zhao   +42 more
core   +2 more sources

Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration

Frontiers in Cell and Developmental Biology, 2023
Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading cause of LBP.
Xiao Yang, Yang Lu, Hang Zhou, Hai-Tao Jiang, Lei Chu   +4 more
doaj   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources