Results 121 to 130 of about 8,727 (225)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Involvement of the serpins, serine-protease inhibitors, from the human gut microbiota in inflammatory bowel diseases

, 2019
Les inhibiteurs des protéases à sérine (Serpins) constituent une classe d'enzymes très peu étudiée chez les bactéries. Dans ce travail de thèse nous nous sommes intéressés à l'étude des serpins provenant du microbiote intestinal et l'investigation de ...
Mkaouar, Héla
core  

The role of serpins in the surveillance of the secretory pathway

, 2007
Ragg H. The role of serpins in the surveillance of the secretory pathway. CELL. MOL. LIFE SCI. 2007;64(21):2763-2770.Serpins (serine protease inhibitors) constitute a class of proteins with an unusually wide spectrum of different functions at ...
Ragg, Hermann
core   +1 more source

Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages

mBio
Serine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored.
Esther Nobs, Katie Laschanzky, Kristina Munke, Elin Movert, Christine Valfridsson, Fredric Carlsson   +5 more
doaj   +1 more source

Serpins prevent granzyme-induced death in a species-specific manner

, 2006
Expression of serine protease inhibitors (serpins) is one of the mechanisms used by tumour cells to escape immune surveillance. Previously, we have shown that expression of serpins SPI-6 and SPI-CI, respectively, renders tumour cells resistant to ...
Bots, Michael, van Bostelen, Liesbeth, Offringa, Rienk, Rademaker, Mirjam Tga, Medema, Jan Paul   +4 more
core   +1 more source

Chopin’s serpin [PDF]

Hepatology, 2003
openaire   +2 more sources

Genetic Alterations in the SERPIN Gene Family as Predictors of Immune Checkpoint Therapy Efficacy in Melanoma and Non‐Small Cell Lung Cancer

Medicine Advances
Background Identifying reliable biomarkers for immune checkpoint therapy response remains a critical challenge in immuno‐oncology. While tumor mutation burden (TMB) effectively predicts treatment outcomes, its clinical implementation is hindered by cost ...
Jieqiong Li, Di Wang, Yuxin Wang, Lixia Wang, Jinmei Luo, Yi Xiao   +5 more
doaj   +1 more source

Endothelial serpins—protectors of the vasculature?

, 1994
SUMMARY Vascular damage, initiated by host inflammatory cells, is a component of the pathophysiology of many acute and chronic inflammatory disorders.
V TALBOT, K D FORSYTH, I BECKMAN
core   +1 more source

Houston, we have a problem: Coagulation concerns during long‐term spaceflight

Experimental Physiology, Volume 111, Issue 9, Page 3880-3883, 1 September 2026.
Lewis Fall, Damian M. Bailey
wiley   +1 more source

Serpin [PDF]

, 2020
openaire   +1 more source