Results 81 to 90 of about 8,727 (225)

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes.

PLoS ONE, 2012
Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins ...
Mohammed Asmal, James B Whitney, Corinne Luedemann, Angela Carville, Robert Steen, Norman L Letvin, Ralf Geiben-Lynn   +6 more
doaj   +1 more source

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, EarlyView.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source

Alignment of human, mouse and opossum serpins.

, 2016
The amino acid sequences of the human serpin B9, human serpin B6, mouse serpin B9 and the closest homolog to these three sequences in the opossum, opossum serpin B6, were aligned using clustal W algorithm in the Lasergene program (DNASTAR Inc, USA).
Michael Thorpe (13907), Zhirong Fu (761536), Srinivas Akula (562159), Lars Hellman (300805)   +3 more
core   +1 more source

A family of serine protease inhibitors (serpins) in the cattle tick Rhipicephalus (Boophilus) microplus [PDF]

, 2014
Proteins belonging to the serine protease inhibitor (serpin) superfamily play essential roles in many organisms. In arthropods these proteins are involved in innate immune system, morphogenesis and development.
Tirloni, Lucas, Seixas, Adriana, Mulenga, Albert, Termignoni, Carlos, da Silva Vaz, Itabajara   +4 more
core   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Differential gene expression of serine protease inhibitors in bovine ovarian follicle: possible involvement in follicular growth and atresia

Reproductive Biology and Endocrinology, 2011
Background SERPINs (serine protease inhibitors) regulate proteases involving fibrinolysis, coagulation, inflammation, cell mobility, cellular differentiation and apoptosis.
Takahashi Toru, Hosoe Misa, Ushizawa Koichi, Hayashi Ken-Go   +3 more
doaj   +1 more source

High Specificity of sIgE to α−/β‐Gliadin and Limited Reactivity to Non‐Gluten Proteins in Wheat Allergy Dependent on Augmentation Factors (WALDA)

Clinical &Experimental Allergy, EarlyView.
This study suggest that WALDA is characterized by highly specific reactivity to gliadin proteins, with limited sensitization to non‐gluten wheat components. sIgE to α‐/β‐gliadin represents a promising diagnostic biomarker with superior specificity compared to ω5‐gliadin alone.
Valentina Faihs, Florian Schusta, Claudia Kugler, Tilo Biedermann, Monika Raulf, Margitta Worm, Knut Brockow, Ingrid Sander   +7 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Genome Wide Identification and Comparative Analysis of the Serpin Gene Family in Brachypodium and Barley

Plants, 2020
Serpins (serine protease inhibitors) constitute one of the largest and most widely distributed superfamilies of protease inhibitors and have been identified in nearly all organisms.
Shazia Rehman, Bodil Jørgensen, Ejaz Aziz, Riffat Batool, Samar Naseer, Søren K. Rasmussen   +5 more
doaj   +1 more source