Viral cross-class serpin inhibits vascular inflammation and T lymphocyte fratricide; a study in rodent models in vivo and human cell lines in vitro. [PDF]
PLoS ONE, 2012 Poxviruses express highly active inhibitors, including serine proteinase inhibitors (serpins), designed to target host immune defense pathways. Recent work has demonstrated clinical efficacy for a secreted, myxomaviral serpin, Serp-1, which targets the ...
Kasinath Viswanathan +14 more
doaj +1 more source
Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema
Allergy, EarlyView.This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery +25 more
wiley +1 more source
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB [PDF]
, 2017 The serpinopathies are human pathologies caused by mutations that promote polymerisation and intracellular deposition of proteins of the serpin superfamily, leading to a poorly understood cell toxicity.
Cacci, Emanuele +10 more
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British Journal of Pharmacology, EarlyView.Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja +11 more
wiley +1 more source
Plants, 2020 Serpins (serine protease inhibitors) constitute one of the largest and most widely distributed superfamilies of protease inhibitors and have been identified in nearly all organisms.
Shazia Rehman +5 more
doaj +1 more source
Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases [PDF]
, 2010 Background The SERPINA1, SERPINA3, and SERPINE2 genes, which encode antiproteases, have been proposed to be susceptible genes for of chronic obstructive pulmonary disease (COPD) and related phenotypes.
Koichi Fujimoto +8 more
core +1 more source
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Transcript profiling of serine- and cysteine protease inhibitors in Triticum aestivum varieties with different drought tolerance [PDF]
, 2016 A high number of protease inhibitors (PI) have been identified in diverse plant species but information about their role in plant stress responses is still fragmentary.
Kirova, E. +3 more
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A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
New data on the lithostratigraphy of Beiras Group (Schist Greywacke Complex) in the region of Góis-Arganil-Pampilhosa da Serra (Central Portugal) [PDF]
, 2013 [Abstract] In the course of geological surveys conducted in the region of Góis (Central Portugal) a new unit was recognized at the top of Boque-Serpins Formation, characterized by the presence of levels of quartzites interlayered with shales, now called ...
Meireles, C.
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