Results 91 to 100 of about 61,716 (249)

Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility. [PDF]

, 2016
Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated.
Ge, Xin, Guo, Xue-Jiang, He, Jun, Jiang, Bing-Hua, Jiang, Cheng-Fei, Li, Dong-Mei, Li, Wei, Lin, Marie, Liu, Ling-Zhi, Liu, Xue, Qian, Xu, Qian, Ying-Chen, Sha, Jia-Hao, Shen, Hua, Shi, Zhu-Mei, Wang, Lin, Wang, Min, Yin, Yu, Zheng, Bo, Zheng, Ji-Tai   +19 more
core   +2 more sources

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

A novel stepwise micro-TESE approach in non obstructive azoospermia [PDF]

, 2016
Background: The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by employing a novel stepwise micro ...
Casciani, V, DE NUNZIO, Cosimo, Dente, Donato, Franco, Giorgio, Greco, Alessia, Greco, E., Greco, Pf, Leonardo, Costantino, Minasi, Mg, Scarselli, F   +9 more
core   +2 more sources

Sertoli cell only syndrome: Status of sertoli cell maturation and function

Indian Journal of Endocrinology and Metabolism, 2012
Mature and functional Sertoli cells are essential for the survival of germ cells in testes. In Sertoli cell only syndrome (SCOS), there is no germ cells. Then, question arises whether absence of germ cells in SCOS secondary to Sertoli cells immaturity or mal function. Sertoli cells maturational and functional status is unclear in SCOS.
Manish Jain, Ashutosh Halder
openaire   +3 more sources

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Post-Thaw Viability and Functionality of Cryopreserved Rat Fetal Brain Cells Cocultured with Sertoli Cells

Cell Transplantation, 1997
Testis-derived Sertoli cells have been used to create an immune “privileged” site outside of the testis to facilitate cell transplantation protocols for diabetes and neurodegenerative diseases.
D.F. Cameron Ph.D., A.I. Othberg, C.V. Borlongan, S. Rashed, A. Anton, S. Saporta, P.R. Sanberg   +6 more
doaj   +1 more source

Coxsackie and adenovirus receptor (CAR) is a product of Sertoli and germ cells in rat testes which is localized at the Sertoli-Sertoli and Sertoli-germ cell interface [PDF]

, 2007
The coxsackie and adenovirus receptor (CAR), a putative cell-cell adhesion molecule, has attracted wide interest due to its importance in viral pathogenesis and in mediating adenoviral gene delivery.
Cheng, CY, Lee, WWM, Mruk, DD, Wang, CQF
core   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, EarlyView.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Sertoli Cell Line Lacks the Immunoprotective Properties Associated with Primary Sertoli Cells

Cell Transplantation, 2008
Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell line ...
Jannette M. Dufour, Brinda Dass, Katie R. Halley, Gregory S. Korbutt, Doreen E. Dixon, Ray V. Rajotte   +5 more
doaj   +1 more source

Development of a nomogram for sperm retrieval at microTESE for idiopathic non‐obstructive azoospermia in a multi‐center cohort study

Andrology, EarlyView.
Abstract Background Non‐obstructive azoospermia (NOA) affects approximately 10% of infertile men and represents a major challenge in assisted reproductive technology (ART). A model that includes histological variants could be helpful in predicting sperm retrieval rate (SRR) after microdissection testicular sperm extraction (mTESE) in patients affected ...
Giorgio Ivan Russo, Edoardo Pozzi, Fausto Negri, Marco Falcone, Emanuele Zupo, Mirko Preto, Maria Giovanna Asmundo, Sandrine Chamayou, Murat Dursun, Ateş Kadıoğlu, Andrea Salonia   +10 more
wiley   +1 more source