Results 31 to 40 of about 61,716 (249)

SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes [PDF]

, 2013
The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (
A Buageaw, A Sada, BT Phillips, D Filipponi, D Lok, D Sweetman, D Sweetman, DG de Rooij, DL van den Berg, E Camp, G Jürgens, H Kubota, H Suzuki, H Yamatani, J Kohlhase, J Kohlhase, J Kohlhase, J Yang, J Yang, K Eildermann, K Koshiba-Takeuchi, K Yoshinaga, K Zheng, Kathrin Gassei, Kyle E. Orwig, M Culty, M Sakaki-Yumoto, M Tokuda, M Warren, MC Hofmann, MJ Oatley, N Uez, PJ Wang, PM Kluin, RA Tegelenbosch, RM Hobbs, RP Kühnlein, S Jing, S Rao, S Yoshida, S Yoshida, S Yuri, Shree Ram Singh, T Hollemann, T Nakagawa, T Oikawa, T Ott, U Elling, X Meng   +48 more
core   +3 more sources

Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Frontiers in Pharmacology, 2020
Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting.
Haixia Zhao, Haixia Zhao, Xu You, Qian Chen, Qian Chen, Siqi Yang, Qiongyan Ma, Yumin He, Yumin He, Chaoqi Liu, Yaoyan Dun, Jie Wu, Changcheng Zhang, Changcheng Zhang, Ding Yuan   +14 more
doaj   +1 more source

Sex determination in mythology and history [PDF]

, 2005
The history of ideas on how the sexes became divided spans at least three thousand years. The biblical account of the origin of Eve, and the opinions of the philosophers of classical Greece, have unexpected bearings on present-day ideas.
Mittwoch, U
core   +2 more sources

RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells

Cell & Bioscience, 2023
Background Spermatogenesis depends on the supporting of the Sertoli cells and their communications with germ cells. However, the regulation of crosstalk between the Sertoli cells and germ cells remains unclear. Results In this report, we used conditional
Fengling Lai, Haoyu Wang, Xinyue Zhao, Kangning Yang, Le Cai, Mengxin Hu, Lan Lin, Xizhong Xia, Wei Li, Hanhua Cheng, Rongjia Zhou   +10 more
doaj   +1 more source

An update on the potential for male contraception : emerging options [PDF]

, 2013
The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Alsaadi, Manal, Ferro, Valerie, Garside, Deborah A, Gebril, Ayman M, Mullen, Alexander, Nimmo, Natalie   +5 more
core   +1 more source

Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Scientific Reports, 2022
AbstractThe Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous tubules containing SC-clusters.
Sarah Staggenborg, Rüdiger Koch, Kristina Rode, Hanna Hüneke, Louiza Tiedje, Gudrun Wirth, Marion Langeheine, Ines Blume, Kerstin Rohn, Christoph Wrede, Christiane Pfarrer, Ralph Brehm   +11 more
openaire   +3 more sources

The Testicular-Derived Sertoli Cell: Cellular Immunoscience to Enable Transplantation

Cell Transplantation, 2003
There is a renewed enthusiasm for the potential of cellular transplantation as a therapy for numerous clinical disorders. The revived interest is largely due to the unprecedented success of the “Edmonton protocol,” which produced a 100% cure rate for ...
Dwaine F. Emerich PH.D, Richelle Hemendinger, Craig R. Halberstadt   +2 more
doaj   +1 more source

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency. [PDF]

, 1996
Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia.
Andersson, Stefan, Blethen, Sandra L., Bloise, Walter, Cutler Jr., Gordon B., Davis, Daphne L., Geissler, Wayne M., Griffin, James E., Grumbach, Melvin M., Mendonca, Berenice B., New, Maria I., Russell, David D., Schwarz, Hans P., Wilson, Jean D., Witchel, Selma F., Wu, Ling   +14 more
core   +1 more source

NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients

Asian Journal of Andrology, 2015
This study was designed to explore the regulatory effects of male germ cell secreting factor NODAL on Sertoli cell fate decisions from obstructive azoospermia (OA) and nonobstructive azoospermia (NOA) patients.
Ru-Hui Tian, Shi Yang, Zi-Jue Zhu, Jun-Long Wang, Yun Liu, Chencheng Yao, Meng Ma, Ying Guo, Qingqing Yuan, Yanan Hai, Yi-Ran Huang, Zuping He, Zheng Li   +12 more
doaj   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Geissler, Claudia, Jochum, Marianne, Naegler, Dorit K., Nerlich, Andreas, Neth, Peter, Profanter, Birgit, Sommerhoff, Christian P.   +6 more
core   +1 more source