Results 71 to 80 of about 4,451,677 (265)

Conditional strategies to study gene function during gonadal development in mammals. [PDF]

, 2008
Sexual development in mammals involves a complex cascade of genetic events. These begin with a cell fate decision, whether to make Sertoli or follicle cells, that gives rise to the development of a male or female gonad, which is controlled by the testis ...
Tye, A.J.
core  

RU 486 blocks inhibitory effect of neonatal corticosterone administration on sertoli cell proliferation in mice

Scientific Reports
Cortisol/corticosterone (CORT) are typical glucocorticoids and exert an anti-stress function. p27, a cyclin-dependent kinase inhibitor, acts as a terminal factor for Sertoli cell proliferation at the prepubescent stage. Our previous study showed neonatal
Hidenobu Miyaso, Yutaro Natsuyama, Shinichi Kawata, Tomiko Yakura, Zhong-Lian Li, Miyuki Kuramasu, Shota Tanifuji, Xi Wu, Yuki Ogawa, Yoshiharu Matsuno, Masahiro Itoh   +10 more
doaj   +1 more source

Trophic Effect of Porcine Sertoli Cells on Rat and Human Ventral Mesencephalic Cells and Hnt Neurons in Vitro

Cell Transplantation, 1998
The poor survival of embryonic dopaminergic (DA) neurons transplanted into patients with Parkinson's disease (PD) has encouraged researchers to search for new methods to affect the short- as well as long-term survival of these neurons after ...
Agneta I. Othberg, Alison E. Willing, Don F. Cameron, Alex Anton, Samuel Saporta, Thomas B. Freeman, Paul R. Sanberg   +6 more
doaj   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, Accepted Article.
Objectives To elucidate role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1KO and β‐TrCP2KO mice, along with myeloid‐specific conditional β‐TrCP2KO (β‐TrCP2ΔM) mice.
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

FGF9 and WNT4 act as antagonistic signals to regulate mammalian sex determination [PDF]

, 2006
The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development.
Robin Lovell-Badge, Sekido, R, Behringer, Richard R, Capel, Blanche, Lovell-Badge, R, DiNapoli, Leo, Blanche Capel, Chaboissier, Marie-Christine, Behringer Richard R, Lovell-Badge, Robin, DiNapoli Leo, Poulat Francis, Behringer, RR, Kim Yuna, Kobayashi, Akio, Poulat, F, Behringer, Richard,, Behringer, Richard, R., Brennan, J, Chaboissier, M-C, Capel, B, Leo DiNapoli, Ryohei Sekido, Kim, Y, Kim, Yuna, Yuna Kim, Marie-Christine Chaboissier, Francis Poulat, Jennifer Brennan, Lovell-Badge Robin, Akio Kobayashi, Kobayashi Akio, DiNapoli, L, Brennan Jennifer, Capel Blanche, Kobayashi, A, Brennan, Jennifer, Richard R Behringer, Poulat, Francis, Chaboissier Marie-Christine, Sekido, Ryohei, Sekido Ryohei   +41 more
core   +1 more source

Identification of a Specific Sertoli Cell Marker, Sox9, for Use in Transplantation

Cell Transplantation, 2002
The immunoprivileged environment of the testes was first described in the 1930s, and the Sertoli cell was later identified as the main cell type responsible for this phenomenon. Recent work has examined the possibility of recreating this immunoprivileged
R. A. Hemendinger, P. Gores, L. Blacksten, V. Harley, C. Halberstadt   +4 more
doaj   +1 more source

Melatonin Promotes the Proliferation of Chicken Sertoli Cells by Activating the ERK/Inhibin Alpha Subunit Signaling Pathway

Molecules, 2020
Melatonin influences physiological processes such as promoting proliferation and regulating cell development and function, and its effects on chicken Sertoli cells are unknown. Therefore, we investigated the effects of melatonin on cell proliferation and
Ke Xu, Jun Wang, Hongyu Liu, Jing Zhao, Wenfa Lu   +4 more
doaj   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics [PDF]

, 2010
Regulation of blood flow through the testicular microvasculature by vasomotion is thought to be important for normal testis function as it regulates interstitial fluid (IF) dynamics which is an important intra-testicular transport medium.
Bergh, A., Sigrid Kilter, Richard M. Sharpe, Philippa T K Saunders, Lindsey Moffat, Sharpe, R.M., Welsh Michelle, Welsh, M., Anders Bergh, Philippa T. K. Saunders, Atanassova Nina, Saunders Philippa T. K., Atanassova, N., Smith, Lee B., Richard M Sharpe, Bergh, Anders, Bergh, Anders,, Kilter Sigrid, Sharpe, Richard M, Michelle Welsh, Sharpe Richard M., Moffat Lindsey, Lee B. Smith, Sharpe, Richard M., Moffat, Lindsey, Smith, L.B., Lee B Smith, Saunders, P.T.K., Kilter, Sigrid, Bergh Anders, Saunders, Philippa T. K.; id_orcid, Welsh, Michelle, Saunders, Philippa TK, Nina Atanassova, Smith Lee B., Smith, Lee B, Moffat, L., Kilter, S., Kilter, Sigrid,, Atanassova, Nina   +39 more
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source