Results 51 to 60 of about 33,143 (262)

Sertoli Cell-Specific Activation of Transforming Growth Factor Beta Receptor 1 Leads to Testicular Granulosa Cell Tumor Formation

Cells, 2023
The transforming growth factor β (TGFβ) superfamily, consisting of protein ligands, receptors, and intracellular SMAD transducers, regulates fundamental biological processes and cancer development.
Xin Fang, Linfeng Nie, Satwikreddy Putluri, Nan Ni, Laurent Bartholin, Qinglei Li   +5 more
doaj   +1 more source

Tuning the Testicular Microenvironment for Enhancing Human Sertoli Cells Maturation and Functionality In Vitro

Advanced Healthcare Materials, EarlyView.
An in vitro testicular model is developed by generating connective tissue equivalents from human dermal fibroblast‐derived microtissues and coupling them with human Sertoli cells or human Sertoli cell spheroids. This engineered microenvironment supports Sertoli cell maturation and functionality, providing a promising platform for studying human ...
Annachiara Scalzone, Giorgia Imparato, Chiara Ausilio, Valentina Mollo, Paolo Antonio Netti   +4 more
wiley   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid

PLoS ONE, 2023
Sertoli cells support the development of sperm and the function of various somatic cells in the interstitium between the tubules. Sertoli cells regulate the function of the testicular vasculature and the development and function of the Leydig cells that ...
Liza O’Donnell, Laura F. Dagley, Michael Curley, Annalucia Darbey, Peter J. O’Shaughnessy, Thorsten Diemer, Adrian Pilatz, Daniela Fietz, Peter G. Stanton, Lee B. Smith, Diane Rebourcet   +10 more
doaj  

Zearalenone induces oxidative stress and autophagy in goat Sertoli cells

Ecotoxicology and Environmental Safety, 2023
Zearalenone (ZEA), one of the non-steroidal estrogen mycotoxin, can cause male reproductive damage and genotoxicity in mammals. Testicular oxidative injury is an important factor causing male sterility.
Xinyu Liu, Huaming Xi, Shuaiqi Han, Hongyun Zhang, Jianhong Hu   +4 more
doaj   +1 more source

Gama-glutamil transpeptidase como alvo de ação da 1,25(OH)2 vitamina D3 na membrana plasmática das células de Sertoli [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2014A 1a,25-diidroxivitamina D3 (1,25-D3) é o metabólito ativo da vitaminaD3. A 1,25-D3 é crítica para
Gonçalves, Renata
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis

Reproductive Biology and Endocrinology, 2022
Follicle-stimulating hormone signaling is essential for the initiation and early stages of spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli cells.
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang, Fu-Qing Tan   +3 more
doaj   +1 more source

miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway

Animals, 2021
The quantity of Sertoli cells in the adult testis decides the daily gamete formation, and accumulating evidence indicates that epigenetic factors regulate the proliferation of Sertoli cells. Research on the function and regulatory mechanism of microRNAs (
Xiangwei Tang, Yao Chen, Hui Luo, Qiao Bian, Bo Weng, Anqi Yang, Dan Chu, Maoliang Ran, Bin Chen   +8 more
doaj   +1 more source

FGF9 and WNT4 act as antagonistic signals to regulate mammalian sex determination [PDF]

, 2006
The genes encoding members of the wingless-related MMTV integration site (WNT) and fibroblast growth factor (FGF) families coordinate growth, morphogenesis, and differentiation in many fields of cells during development.
Robin Lovell-Badge, Sekido, R, Behringer, Richard R, Capel, Blanche, Lovell-Badge, R, DiNapoli, Leo, Blanche Capel, Chaboissier, Marie-Christine, Behringer Richard R, Lovell-Badge, Robin, DiNapoli Leo, Poulat Francis, Behringer, RR, Kim Yuna, Kobayashi, Akio, Poulat, F, Behringer, Richard,, Behringer, Richard, R., Brennan, J, Chaboissier, M-C, Capel, B, Leo DiNapoli, Ryohei Sekido, Kim, Y, Kim, Yuna, Yuna Kim, Marie-Christine Chaboissier, Francis Poulat, Jennifer Brennan, Lovell-Badge Robin, Akio Kobayashi, Kobayashi Akio, DiNapoli, L, Brennan Jennifer, Capel Blanche, Kobayashi, A, Brennan, Jennifer, Richard R Behringer, Poulat, Francis, Chaboissier Marie-Christine, Sekido, Ryohei, Sekido Ryohei   +41 more
core   +1 more source