Results 31 to 40 of about 33,143 (262)

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Frontiers in Endocrinology, 2021
Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shah, Ranjha Khan, Basit Shah, Asad Khan, Sobia Dil, Wei Liu, Jie Wen, Xiaohua Jiang   +7 more
doaj   +1 more source

A Human Gonadal Cell Model From Induced Pluripotent Stem Cells

Frontiers in Genetics, 2018
Sertoli cells are main players in the male gonads development and their study may shed light on 46,XY disorders of sex development (DSD). Mature primary Sertoli cells are incapable of proliferating in prolonged in vitro cultures and the available Sertoli
Daniel Rodríguez Gutiérrez, Wassim Eid, Wassim Eid, Anna Biason-Lauber   +3 more
doaj   +1 more source

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development [PDF]

, 2010
Peer ...
Richard M. Sharpe, Philippa T K Saunders, Sergio R. Batlouni, Batlouni, Sergio R., Luiz R França, Esnal, Arantza; id_orcid, Batlouni, Sergio R. [UNESP], Karel De Gendt, Arantza Esnal, Esnal Arantza, Verhoeven Guido, Batlouni, Sergio R, De Gendt Karel, Philippa T. K. Saunders, Johannes V Swinnen, Swinnen, Johannes V., Saunders Philippa T. K., Johannes V. Swinnen, Sergio R Batlouni, Saunders, Philippa T K; id_orcid, França Luiz R., Richard M Sharpe, França, Luiz R, Saunders, Philippa T. K., Saunders, Philippa T.K., Sharpe, Richard M, Luiz R. França, Guido Verhoeven, Sharpe Richard M., Saunders, Philippa T K, Ariane Willems, Sharpe, Richard M., Batlouni Sergio R., Swinnen, Johannes V, Swinnen Johannes V., Willems, Ariane, Esnal, Arantza, Verhoeven, Guido, De Gendt, Karel, Swinnen, Johan, Franca, Luiz R., Willems Ariane   +41 more
core   +1 more source

A Unique Cytoplasmic Marker for Extratesticular Sertoli Cells

Cell Transplantation, 2002
In the absence of a definitive cell marker for testis-derived Sertoli cells, their identification in cell culture or in Sertoli cell-facilitated cell transplantation protocols is difficult and limits the creditable evaluation of experimental results ...
D. F. Cameron Ph.D., J. J. Hushen, T. Dejarlais, L. Colado, K. M. Wolski, P. R. Sanberg, S. Saporta   +6 more
doaj   +1 more source

Androblastoma—Sertoli Cell Tumor

Journal of Urology, 1974
An androblastoma in an undescended testicle of a 43 yr old man is reported. Microscopically, the tumor showed zones of neoplastic cells varying in size and shape and separated by fibrous tissue. In some areas the cells were round with eosinophilic cytoplasm and round nuclei. No mitoses were seen.
Kalis, E.G., Goulandris, N.D.
openaire   +3 more sources

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Hu, Z.Y., Hu, Z., Verhoeven, G., De Gendt, K., Dandekar, D., Wilkinson, M.F., Wilkinson, M., O'Shaughnessy, P.J.   +7 more
core   +1 more source

PRC1 suppresses a female gene regulatory network to ensure testicular differentiation

Cell Death and Disease, 2023
Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing female sexual ...
So Maezawa, Masashi Yukawa, Kazuteru Hasegawa, Ryo Sugiyama, Mizuho Iizuka, Mengwen Hu, Akihiko Sakashita, Miguel Vidal, Haruhiko Koseki, Artem Barski, Tony DeFalco, Satoshi H. Namekawa   +11 more
doaj   +1 more source

Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Scientific Reports, 2022
AbstractThe Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous tubules containing SC-clusters.
Sarah Staggenborg, Rüdiger Koch, Kristina Rode, Hanna Hüneke, Louiza Tiedje, Gudrun Wirth, Marion Langeheine, Ines Blume, Kerstin Rohn, Christoph Wrede, Christiane Pfarrer, Ralph Brehm   +11 more
openaire   +3 more sources

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation

Stem Cell Research & Therapy, 2019
Background Sertoli cells are the most important somatic cells contributing to the microenvironment (named niche) for spermatogonial stem cells (SSCs). They produce amounts of crucial growth factors and structure proteins that play essential roles in the ...
Ruhui Tian, Chencheng Yao, Chao Yang, Zijue Zhu, Chong Li, Erlei Zhi, Junlong Wang, Peng Li, Huixing Chen, Qingqing Yuan, Zuping He, Zheng Li   +11 more
doaj   +1 more source