Results 31 to 40 of about 4,451,677 (265)

Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation

Stem Cell Research & Therapy, 2019
Background Sertoli cells are the most important somatic cells contributing to the microenvironment (named niche) for spermatogonial stem cells (SSCs). They produce amounts of crucial growth factors and structure proteins that play essential roles in the ...
Ruhui Tian, Chencheng Yao, Chao Yang, Zijue Zhu, Chong Li, Erlei Zhi, Junlong Wang, Peng Li, Huixing Chen, Qingqing Yuan, Zuping He, Zheng Li   +11 more
doaj   +1 more source

Post-Thaw Viability and Functionality of Cryopreserved Rat Fetal Brain Cells Cocultured with Sertoli Cells

Cell Transplantation, 1997
Testis-derived Sertoli cells have been used to create an immune “privileged” site outside of the testis to facilitate cell transplantation protocols for diabetes and neurodegenerative diseases.
D.F. Cameron Ph.D., A.I. Othberg, C.V. Borlongan, S. Rashed, A. Anton, S. Saporta, P.R. Sanberg   +6 more
doaj   +1 more source

The Expression of TLR2 and TLR3 in Sertoli Cells of Azoospermic Patients

Cell Journal, 2017
Objective: Toll-like receptors (TLRs) on Sertoli cells are thought to have essential roles in sperm protection. This study was conducted to investigate the expression of TLR2 and TLR3 in Sertoli cells of men with azoospermia. Materials and Methods: In
Mohammad Reza Lakpour, Morteza Koruji, Abdolhossein Shahverdi, Samaneh Aghajanpour, Majid Rajabian Naghandar, Mohammad Ali Sadighi Gilani, Marjan Sabbaghian, Reza Aflatoonian   +7 more
doaj   +1 more source

Accumulation of Seminolipid in Sertoli Cells Is Associated with Increased Levels of Reactive Oxygen Species and Male Subfertility: Studies in Aging Arsa Null Male Mice

Antioxidants, 2021
Seminolipid (also known as sulfogalactosylglycerolipid-SGG), present selectively in male germ cells, plays important roles in spermatogenesis and sperm–egg interaction. The proper degradation of SGG in apoptotic germ cells is also as important.
Kessiri Kongmanas, Arpornrad Saewu, Wongsakorn Kiattiburut, Mark A Baker, Kym F Faull, Dylan Burger, Nongnuj Tanphaichitr   +6 more
doaj   +1 more source

Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis

, 2022
The long-standing knowledge that Sertoli cells determine fetal testosterone production levels is not widespread, despite being first reported over a decade ago in studies of mice.
Loveland, Kate L, Whiley, Penny A. F., Whiley, Penny AF, Loveland, Kate L., O'Donnell, Liza, O’Donnell, Liza   +5 more
core   +1 more source

The role of estrogen receptors in rat Sertoli cells at different stages of development

Heliyon, 2020
The aim of the study was to investigate the effects of estrogen receptors (ESR1 and ESR2) on the expression of the proteins involved with proliferation (CCND1) and differentiation (CDKN1B and CTNNB) of Sertoli cells from rat in different stages of ...
Carla Macheroni, Thaís Fabiana Gameiro Lucas, Catarina Segreti Porto   +2 more
doaj   +1 more source

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours [PDF]

, 2007
Background: Sertoli-Leyclig cell tumours of the ovary account for only 0.2% of malignant ovarian tumours. Two-thirds of all patients become apparent due to the tumour's hormone production. Methods: A 41-year-old patient (gravida 4, para 4) presented with
Kuemper, Caroline, Diebold, Joachim, Lenhard, Miriam, Ditsch, Nina, Friese, Klaus, Burges, Alexander, Stieber, Petra   +6 more
core   +1 more source

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

Journal of Lipid Research, 2004
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis.
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington   +9 more
doaj   +1 more source

Sertoli cells as key drivers of testis function

, 2022
Sertoli cells are the orchestrators of spermatogenesis; they support fetal germ cell commitment to the male pathway and are essential for germ cell development, from maintenance of the spermatogonial stem cell niche and spermatogonial populations ...
Smith, LB, Rebourcet, D, O'Donnell, L
core   +1 more source

Sertoli Cell Line Lacks the Immunoprotective Properties Associated with Primary Sertoli Cells

Cell Transplantation, 2008
Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell line ...
Jannette M. Dufour, Brinda Dass, Katie R. Halley, Gregory S. Korbutt, Doreen E. Dixon, Ray V. Rajotte   +5 more
doaj   +1 more source