Asian Journal of Andrology, 2015 This study was designed to explore the regulatory effects of male germ cell secreting factor NODAL on Sertoli cell fate decisions from obstructive azoospermia (OA) and nonobstructive azoospermia (NOA) patients.
Ru-Hui Tian +12 more
doaj +1 more source
The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation
Frontiers in Endocrinology, 2021 Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shah +7 more
doaj +1 more source
A Human Gonadal Cell Model From Induced Pluripotent Stem Cells
Frontiers in Genetics, 2018 Sertoli cells are main players in the male gonads development and their study may shed light on 46,XY disorders of sex development (DSD). Mature primary Sertoli cells are incapable of proliferating in prolonged in vitro cultures and the available Sertoli
Daniel Rodríguez Gutiérrez +3 more
doaj +1 more source
A Unique Cytoplasmic Marker for Extratesticular Sertoli Cells
Cell Transplantation, 2002 In the absence of a definitive cell marker for testis-derived Sertoli cells, their identification in cell culture or in Sertoli cell-facilitated cell transplantation protocols is difficult and limits the creditable evaluation of experimental results ...
D. F. Cameron Ph.D. +6 more
doaj +1 more source
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
core +1 more source
Androblastoma—Sertoli Cell Tumor
Journal of Urology, 1974 An androblastoma in an undescended testicle of a 43 yr old man is reported. Microscopically, the tumor showed zones of neoplastic cells varying in size and shape and separated by fibrous tissue. In some areas the cells were round with eosinophilic cytoplasm and round nuclei. No mitoses were seen.
Kalis, E.G., Goulandris, N.D.
openaire +3 more sources
Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]
, 2010 Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Hu, Z.Y. +7 more
core +1 more source
Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice [PDF]
, 2003 During mammalian testis development distinct generations of fetal and adult Leydig cells arise. Luteinising hormone (LH) is required for normal adult Leydig cell function and for the establishment of normal adult Leydig cell number but its role in the ...
Baker, P.J. +4 more
core +7 more sources
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation
Cell Death and Disease, 2023 Gonadal sex determination and differentiation are controlled by somatic support cells of testes (Sertoli cells) and ovaries (granulosa cells). In testes, the epigenetic mechanism that maintains chromatin states responsible for suppressing female sexual ...
So Maezawa +11 more
doaj +1 more source
Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development [PDF]
, 2010 Peer ...
Richard M. Sharpe +41 more
core +1 more source