Results 11 to 20 of about 33,143 (262)

Long-term effects of early postnatal stress on Sertoli cells [PDF]

Frontiers in Genetics, 2022
Sertoli cells are somatic cells in testis essential for spermatogenesis, that support the development, maturation, and differentiation of germ cells.
Kristina M. Thumfart, Samuel Lazzeri, Samuel Lazzeri, Samuel Lazzeri, Francesca Manuella, Isabelle M. Mansuy   +5 more
doaj   +2 more sources

Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]

PLoS ONE, 2012
Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy, Ana Monteiro, Margaret Abel   +2 more
doaj   +3 more sources

The impact of Connexin 43 deficiency on the cell shape and cytoskeleton of murine Sertoli cells: A house with ramshackle walls? [PDF]

PLoS ONE
Genetically induced loss of the gap-junction protein Connexin 43 (Cx43) in murine Sertoli cells leads to an arrest of spermatogenesis at the level of spermatogonia, highly vacuolated tubules, and intratubular cell clusters.
Mareike Ueffing, Marion Langeheine, Sarah Gniesmer, Kristina Rode, Sarah Staggenborg, Gudrun Wirth, Kerstin Rohn, Rüdiger Koch, Ines Blume, Christiane Pfarrer, Christoph Wrede, Ralph Brehm   +11 more
doaj   +2 more sources

Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis.

PLoS ONE, 2014
The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis.
Diane Rebourcet, Peter J O'Shaughnessy, Ana Monteiro, Laura Milne, Lyndsey Cruickshanks, Nathan Jeffrey, Florian Guillou, Tom C Freeman, Rod T Mitchell, Lee B Smith   +9 more
doaj   +2 more sources

RAD21L1 Is Sufficient and Effective for Reprogramming Human Sertoli Cells to Phenotypic Spermatogonial Stem Cells Through DNA Methylation and Essential for Male Fertility [PDF]

Advanced Science
It remains unknown about molecular mechanisms underlying the transition of somatic cells into male germ cells. It is observed that RAD21L1 transcript is upregulated during reprogramming of Sertoli cells into human spermatogonial stem cells (SSCs) by ...
Caimei He, Yinghong Cui, Wei Chen, Chunyun Li, Zuping He   +4 more
doaj   +2 more sources

Characterization and Functionality of Proliferative Human Sertoli Cells

Cell Transplantation, 2011
It has long been thought that mammalian Sertoli cells are terminally differentiated and nondividing postpuberty. For most previous in vitro studies immature rodent testes have been the source of Sertoli cells and these have shown little proliferative ...
Kitty Chui, Alpa Trivedi, C. Yan Cheng, Diana B. Cherbavaz, Paul F. Dazin, Ai Lam Thu Huynh, James B. Mitchell, Gabriel A. Rabinovich, Linda J. Noble-Haeusslein, Constance M. John Ph.D.   +9 more
doaj   +2 more sources

Sertoli cell only syndrome: Status of sertoli cell maturation and function

Indian Journal of Endocrinology and Metabolism, 2012
Background of the study: Mature and functional Sertoli cells are essential for the survival of germ cells in testes. In Sertoli cell only syndrome (SCOS), there is no germ cells.
Manish Jain, Ashutosh Halder
doaj   +3 more sources

Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak [PDF]

BMC Veterinary Research
Background To study the problem of male sterility of cattle-yak and improve the yak crossbreeding, this study obtained the testicular Sertoli cells of yak and cattle-yak and compared the differences in transcriptome levels between the two bovine species.
Xue-Mei Chen, Ming-Xiu Wang, Peng Zhang, Ke-Min Jing, Bing-Lin Yue, Zhi-Juan Wu, Zhi-Xin Chai, Xin-Rui Liu, Jin-Cheng Zhong, Xin Cai   +9 more
doaj   +2 more sources

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source

Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

Frontiers in Endocrinology, 2022
Since their initial description by Enrico Sertoli in 1865, Sertoli cells have continued to enchant testis biologists. Testis size and germ cell carrying capacity are intimately tied to Sertoli cell number and function.
Victor A. Ruthig, Victor A. Ruthig, Dolores J. Lamb, Dolores J. Lamb   +3 more
doaj   +1 more source