Results 11 to 20 of about 25,804 (162)

E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice

Animals, 2020
In the mammalian testes, Sertoli cells are the only somatic cells in the seminiferous tubules that provide structural, nutritional and regulatory support for developing spermatogenic cells.
Rong-Ge Yan, Qi-Lin Yang, Qi-En Yang
doaj   +1 more source

RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells

Cell & Bioscience, 2023
Background Spermatogenesis depends on the supporting of the Sertoli cells and their communications with germ cells. However, the regulation of crosstalk between the Sertoli cells and germ cells remains unclear. Results In this report, we used conditional
Fengling Lai, Haoyu Wang, Xinyue Zhao, Kangning Yang, Le Cai, Mengxin Hu, Lan Lin, Xizhong Xia, Wei Li, Hanhua Cheng, Rongjia Zhou   +10 more
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Role of Testosterone in Maintaining Polarity and Differentiated State of Sertoli Cells [PDF]

Translational Research in Urology, 2023
Differentiation and migration of spermatogonial stem cells (SSCs) from the basal to the adluminal compartment of the seminiferous tubules require a well-specialised scaffold created by a well-developed cytoskeleton in the large cytoplasm of the Sertoli ...
Keykavos Gholami, Sayed Mohammed Jawad Alwedaie   +1 more
doaj   +1 more source

Sertoli Cell Immune Regulation: A Double-Edged Sword

Frontiers in Immunology, 2022
The testis must create and maintain an immune privileged environment to protect maturing germ cells from autoimmune destruction. The establishment of this protective environment is due, at least in part, to Sertoli cells.
Rachel L. Washburn, Rachel L. Washburn, Taylor Hibler, Taylor Hibler, Gurvinder Kaur, Gurvinder Kaur, Jannette M. Dufour, Jannette M. Dufour, Jannette M. Dufour   +8 more
doaj   +1 more source

Apigenin induces oxidative stress in mouse Sertoli TM4 cells [PDF]

Veterinary World, 2021
Background and Aim: Apigenin (API) is an estrogenic compound found in many plants. Sertoli cells reside in the testis and are a key target of environmental toxicants.
Sathaporn Jittapalapong, Thapanee Poompoung, Samak Sutjarit   +2 more
doaj   +1 more source

miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/β-Catenin Signaling

Molecular Therapy: Nucleic Acids, 2019
MicroRNAs (miRNAs) play important roles in mammalian spermatogenesis, which is highly dependent on Sertoli cells. However, the functions and mechanisms of miRNAs in regulating human Sertoli cells remain largely unknown.
Chao Yang, Chencheng Yao, Ruhui Tian, Zijue Zhu, Liangyu Zhao, Peng Li, Huixing Chen, Yuhua Huang, Erlei Zhi, Yuehua Gong, Yunjing Xue, Hong Wang, Qingqing Yuan, Zuping He, Zheng Li   +14 more
doaj   +1 more source

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Frontiers in Endocrinology, 2021
Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways.
Wasim Shah, Ranjha Khan, Basit Shah, Asad Khan, Sobia Dil, Wei Liu, Jie Wen, Xiaohua Jiang   +7 more
doaj   +1 more source

NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients

Asian Journal of Andrology, 2015
This study was designed to explore the regulatory effects of male germ cell secreting factor NODAL on Sertoli cell fate decisions from obstructive azoospermia (OA) and nonobstructive azoospermia (NOA) patients.
Ru-Hui Tian, Shi Yang, Zi-Jue Zhu, Jun-Long Wang, Yun Liu, Chencheng Yao, Meng Ma, Ying Guo, Qingqing Yuan, Yanan Hai, Yi-Ran Huang, Zuping He, Zheng Li   +12 more
doaj   +1 more source

Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Scientific Reports, 2022
AbstractThe Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous tubules containing SC-clusters.
Sarah Staggenborg, Rüdiger Koch, Kristina Rode, Hanna Hüneke, Louiza Tiedje, Gudrun Wirth, Marion Langeheine, Ines Blume, Kerstin Rohn, Christoph Wrede, Christiane Pfarrer, Ralph Brehm   +11 more
openaire   +3 more sources

A Human Gonadal Cell Model From Induced Pluripotent Stem Cells

Frontiers in Genetics, 2018
Sertoli cells are main players in the male gonads development and their study may shed light on 46,XY disorders of sex development (DSD). Mature primary Sertoli cells are incapable of proliferating in prolonged in vitro cultures and the available Sertoli
Daniel Rodríguez Gutiérrez, Wassim Eid, Wassim Eid, Anna Biason-Lauber   +3 more
doaj   +1 more source