Results 11 to 20 of about 4,451,677 (265)

Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. [PDF]

PLoS ONE, 2012
Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Peter J O'Shaughnessy, Ana Monteiro, Margaret Abel   +2 more
doaj   +3 more sources

Hsa-miR-100-3p Controls the Proliferation, DNA Synthesis, and Apoptosis of Human Sertoli Cells by Binding to SGK3

Frontiers in Cell and Developmental Biology, 2021
Human Sertoli cell is required for completing normal spermatogenesis, and significantly, it has important applications in reproduction and regenerative medicine because of its great plasticity.
Bang Liu, Yinghong Cui, Wei Chen, Li Du, Chunyun Li, Cailin Wan, Zuping He   +6 more
doaj   +1 more source

RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells

Cell & Bioscience, 2023
Background Spermatogenesis depends on the supporting of the Sertoli cells and their communications with germ cells. However, the regulation of crosstalk between the Sertoli cells and germ cells remains unclear. Results In this report, we used conditional
Fengling Lai, Haoyu Wang, Xinyue Zhao, Kangning Yang, Le Cai, Mengxin Hu, Lan Lin, Xizhong Xia, Wei Li, Hanhua Cheng, Rongjia Zhou   +10 more
doaj   +1 more source

Role of Testosterone in Maintaining Polarity and Differentiated State of Sertoli Cells [PDF]

Translational Research in Urology, 2023
Differentiation and migration of spermatogonial stem cells (SSCs) from the basal to the adluminal compartment of the seminiferous tubules require a well-specialised scaffold created by a well-developed cytoskeleton in the large cytoplasm of the Sertoli ...
Keykavos Gholami, Sayed Mohammed Jawad Alwedaie   +1 more
doaj   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/β-Catenin Signaling

Molecular Therapy: Nucleic Acids, 2019
MicroRNAs (miRNAs) play important roles in mammalian spermatogenesis, which is highly dependent on Sertoli cells. However, the functions and mechanisms of miRNAs in regulating human Sertoli cells remain largely unknown.
Chao Yang, Chencheng Yao, Ruhui Tian, Zijue Zhu, Liangyu Zhao, Peng Li, Huixing Chen, Yuhua Huang, Erlei Zhi, Yuehua Gong, Yunjing Xue, Hong Wang, Qingqing Yuan, Zuping He, Zheng Li   +14 more
doaj   +1 more source

Sertoli Cell Immune Regulation: A Double-Edged Sword

Frontiers in Immunology, 2022
The testis must create and maintain an immune privileged environment to protect maturing germ cells from autoimmune destruction. The establishment of this protective environment is due, at least in part, to Sertoli cells.
Rachel L. Washburn, Rachel L. Washburn, Taylor Hibler, Taylor Hibler, Gurvinder Kaur, Gurvinder Kaur, Jannette M. Dufour, Jannette M. Dufour, Jannette M. Dufour   +8 more
doaj   +1 more source

Apigenin induces oxidative stress in mouse Sertoli TM4 cells [PDF]

Veterinary World, 2021
Background and Aim: Apigenin (API) is an estrogenic compound found in many plants. Sertoli cells reside in the testis and are a key target of environmental toxicants.
Sathaporn Jittapalapong, Thapanee Poompoung, Samak Sutjarit   +2 more
doaj   +1 more source

Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Scientific Reports, 2022
AbstractThe Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous tubules containing SC-clusters.
Sarah Staggenborg, Rüdiger Koch, Kristina Rode, Hanna Hüneke, Louiza Tiedje, Gudrun Wirth, Marion Langeheine, Ines Blume, Kerstin Rohn, Christoph Wrede, Christiane Pfarrer, Ralph Brehm   +11 more
openaire   +3 more sources

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
core   +1 more source