Results 81 to 90 of about 32,723 (247)
Andrology, EarlyView.ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda +7 more
wiley +1 more source
mRNAs Encoding a von Ebner's-like Protein and the Huntington Disease Protein Are Induced in Rat Male Germ Cells by Sertoli Cells [PDF]
, 1999 Viqar Syed, Edith Gomez, Norman B. Hecht
openalex +1 more source
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis
Andrology, EarlyView.ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan +10 more
wiley +1 more source
Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice
Andrology, EarlyView.ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda +2 more
wiley +1 more source
Thyroid hormone effects on androgen receptor messenger RNA expression in rat Sertoli and peritubular cells [PDF]
, 1998 NK Arambepola, David Bunick, PS Cooke
openalex +1 more source
The sclerosing Sertoli cell tumor of the testis is an extremely rare entity [PDF]
, 2020 Faaz Salah Gomha +9 more
openalex +1 more source
Andrology, EarlyView.ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik +3 more
wiley +1 more source
Characterization and Functionality of Proliferative Human Sertoli Cells
Cell Transplantation, 2011 It has long been thought that mammalian Sertoli cells are terminally differentiated and nondividing postpuberty. For most previous in vitro studies immature rodent testes have been the source of Sertoli cells and these have shown little proliferative ...
Kitty Chui +9 more
doaj +1 more source
BJU International, EarlyView.Objectives To evaluate the diagnostic performance of the Conformité Européenne [CE]‐certified microRNA‐371a‐3p (miR371a) assay in patients undergoing inguinal exploration for small testicular masses of unknown histology in a real‐world setting. Patients and Methods Between March 2023 and March 2024, 60 patients underwent inguinal exploration for ...
Felix Seelemeyer +6 more
wiley +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Context Adult data indicate that hypogonadism is underdiagnosed and undertreated in Prader‐Willi Syndrome (PWS). Objectives We aimed to describe the spectrum of pubertal development, and the diagnosis and treatment of hypogonadism in paediatric/adolescent patients with PWS. Design/Patients A retrospective cohort study of patients with PWS aged
Helen Nguyen +2 more
wiley +1 more source