Results 21 to 30 of about 24,058 (175)

Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoring

Frontiers in Pharmacology
Background: Sertraline is a commonly employed antidepressant in clinical practice. In order to control the plasma concentration of sertraline within the therapeutic window to achieve the best effect and avoid adverse reactions, a personalized model to ...
Ran Fu, Ran Fu, Xin Hao, Jing Yu, Jing Yu, Donghan Wang, Donghan Wang, Jinyuan Zhang, Ze Yu, Fei Gao, Chunhua Zhou, Chunhua Zhou   +11 more
doaj   +1 more source

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

Neurobiology of Disease, 2008
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder resulting from CAG repeat expansion in the gene that encodes for the protein huntingtin.
Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A. Ross   +9 more
doaj   +1 more source

Population pharmacokinetic approach to guide personalized sertraline treatment in Chinese patients

Heliyon
Object: Sertraline is a first-line SSRI for the treatment of depression and has the same effectiveness along with a superior safety profile compared to other medications.
Zi Zhang, Zhihao Guo, Yaqian Tan, Lu Li, Zhanzhang Wang, Yuguan Wen, Shanqing Huang, Dewei Shang   +7 more
doaj   +1 more source

Treatment with high-dose antidepressants severely exacerbates the pathological outcome of experimental Escherichia coli infections in poultry. [PDF]

PLoS ONE, 2017
There is an urgent need for novel antibiotics as the current antibiotics are losing their value due to increased resistance among clinically important bacteria. Sertraline, an on-marked anti-depressive drug, has been shown to modify bacterial activity in
Sofie Kromann, Egle Kudirkiene, Lili Li, Ida Thoefner, Elisabeth Daldorph, Jens Peter Christensen, Hecheng Meng, Rikke Heidemann Olsen   +7 more
doaj   +1 more source

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial

BMC Pharmacology and Toxicology, 2022
Background Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20–30%, and satisfactory treatment is obtained in 40–60% of patients with OCD.
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan   +7 more
doaj   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Detecting serotonin system in rats with myocardial infarction and/or depression after selective serotonin reuptake inhibitor therapy

Heart and Mind, 2017
Objectives: The aim of this study is to explore the effects on serotonergic system of sertraline in the Sprague–Dawley (SD) rats of myocardial infarction (MI), depression, and depression post-MI.
Yanping Ren, Lijun Zhang, Wanlin Wei, Meiyan Liu   +3 more
doaj   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Histological and Histometrical Study of Prostate Following Administration of Sertraline in Adult Mice

Iranian South Medical Journal, 2020
Background: Sertraline, along with its beneficial antidepressant effects, may have adverse effects on the fertility and reproductive system. In recent years, the negative effects of sertraline on body tissues have been shown to some extent.
Hassan Morovvati, Mohammadkazem Koohi, Zabihollah Khaksar, Freshteh Morshedi, Hojat Anbara, Fatemeh Parsaei, Mehdi Hadijafari, Hamidreza Moradi   +7 more
doaj