Results 31 to 40 of about 31,475 (230)

Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy

American Journal of Ophthalmology Case Reports, 2018
Purpose: To describe the presentation, clinical course and management of a patient with bilateral maculopathy associated with sertraline. Observations: We report a rare case of bilateral cystoid macular edema and subretinal fluid in a 78-year-old Asian ...
Aniruddha Agarwal, Kanika Aggarwal, Aman Kumar, Vishali Gupta   +3 more
doaj   +1 more source

Characterization of Anticholinergic Medication Use and Its Associations With Everyday Memory Problems and Cognitive Decline in Autistic Adults With Higher Support Needs

Autism Research, EarlyView.
ABSTRACT Among older adults in the general population, medications with anticholinergic (AC) effects are associated with declines in cognitive functioning and with dementia and Alzheimer's disease. Autistic people have high rates of co‐occurring medical conditions and polypharmacy across the lifespan; thus, they may be at particularly high risk of ...
Goldie A. McQuaid, Nancy Raitano Lee, Gregory L. Wallace   +2 more
wiley   +1 more source

RAPID, SENSITIVE, NEW AND SIMPLE UPLC-MS/MS VALIDATED METHOD WITH CHARGED SURFACE HYBRID COLUMN FOR DETERMINATION OF ANTI DEPRESSION DRUG SERTRALINE IN HUMAN PLASMA AND ITS APPLICATION TO BIOEQUIVALENCE STUDY [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Background: A rapid, simple, sensitive, reproducible, and RP-UPLC-MS/MS method was established and bioanalytically validated for determining Anti depression drug sertraline in human plasma.Methods: Sertraline was extracted from human plasma by protein ...
Yasser Elshayep, waheed Salem, Abdelhameed Ismail, Fathy Abd allah   +3 more
doaj   +1 more source

Sertraline in pregnancy - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood [PDF]

, 2017
Rationale: This study is the first to measure and correlate sertraline concentrations in maternal blood, amniotic fluid and umbilical cord blood and account for distribution of the drug between these three compartments.
Gründer, Gerhard, Goecke, Tamme W., Schoretsanitis, Georgios, Stickeler, Elmar, Goecke, Tamme, Paulzen, Michael   +5 more
core   +1 more source

Antidepressant Prescribing Trends for Adults With and Without Autism in the United Kingdom From 1997 to 2023: A Population‐Based Cohort Study Using Clinical Practice Research Datalink Aurum

Autism Research, EarlyView.
ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non‐autistic males and females in the United Kingdom (UK) from 1997 to 2023.
Aws Sadik, Golam M. Khandaker, Antonio F. Pardiñas, Michael Lundberg, Brian K. Lee, Cecilia Magnusson, Dheeraj Rai, Paul Madley‐Dowd   +7 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Folic Acid Mitigates Sertraline-Induced Liver Damage in Adult Female Albino Rats During Pregnancy and Postpartum: A Biochemical and Histological Study

Medicina
Background and Objectives: Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is frequently prescribed during pregnancy to treat mood disorders.
Ayman A. Refai, Mohammad I. Jumaa, Einas M. Yousef, Ala M. Aljehani, Rana Ahmed Alduraywish, Mohamed R. Elkabary, Safaa M. Hanafy, Hanan S. Seleem, Eman S. El-Roghy   +8 more
doaj   +1 more source

Detecting serotonin system in rats with myocardial infarction and/or depression after selective serotonin reuptake inhibitor therapy

Heart and Mind, 2017
Objectives: The aim of this study is to explore the effects on serotonergic system of sertraline in the Sprague–Dawley (SD) rats of myocardial infarction (MI), depression, and depression post-MI.
Yanping Ren, Lijun Zhang, Wanlin Wei, Meiyan Liu   +3 more
doaj   +1 more source

Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial

BMC Pharmacology and Toxicology, 2022
Background Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20–30%, and satisfactory treatment is obtained in 40–60% of patients with OCD.
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan   +7 more
doaj   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source