Results 31 to 40 of about 29,187 (219)

Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoring

Frontiers in Pharmacology
Background: Sertraline is a commonly employed antidepressant in clinical practice. In order to control the plasma concentration of sertraline within the therapeutic window to achieve the best effect and avoid adverse reactions, a personalized model to ...
Ran Fu, Ran Fu, Xin Hao, Jing Yu, Jing Yu, Donghan Wang, Donghan Wang, Jinyuan Zhang, Ze Yu, Fei Gao, Chunhua Zhou, Chunhua Zhou   +11 more
doaj   +1 more source

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

Neurobiology of Disease, 2008
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder resulting from CAG repeat expansion in the gene that encodes for the protein huntingtin.
Wenzhen Duan, Qi Peng, Naoki Masuda, Eric Ford, Erik Tryggestad, Bruce Ladenheim, Ming Zhao, Jean Lud Cadet, John Wong, Christopher A. Ross   +9 more
doaj   +1 more source

Catalytic Asymmetric Synthesis of Diarylacetates and 4,4-Diarylbutanoates. A Formal Asymmetric Synthesis of (+)-Sertraline

, 2016
The intermolecular C−H insertion chemistry of phenyldiazoacetates catalyzed by dirhodium tetrakis((S)-N-(dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4) can be effectively carried out on cyclohexadienes, leading to the asymmetric synthesis of ...
Douglas G. Stafford (1336788), Huw M. L. Davies (1336170), Tore Hansen (2078749)   +2 more
core   +1 more source

Population pharmacokinetic approach to guide personalized sertraline treatment in Chinese patients

Heliyon
Object: Sertraline is a first-line SSRI for the treatment of depression and has the same effectiveness along with a superior safety profile compared to other medications.
Zi Zhang, Zhihao Guo, Yaqian Tan, Lu Li, Zhanzhang Wang, Yuguan Wen, Shanqing Huang, Dewei Shang   +7 more
doaj   +1 more source

Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy

American Journal of Ophthalmology Case Reports, 2018
Purpose: To describe the presentation, clinical course and management of a patient with bilateral maculopathy associated with sertraline. Observations: We report a rare case of bilateral cystoid macular edema and subretinal fluid in a 78-year-old Asian ...
Aniruddha Agarwal, Kanika Aggarwal, Aman Kumar, Vishali Gupta   +3 more
doaj   +1 more source

RAPID, SENSITIVE, NEW AND SIMPLE UPLC-MS/MS VALIDATED METHOD WITH CHARGED SURFACE HYBRID COLUMN FOR DETERMINATION OF ANTI DEPRESSION DRUG SERTRALINE IN HUMAN PLASMA AND ITS APPLICATION TO BIOEQUIVALENCE STUDY [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Background: A rapid, simple, sensitive, reproducible, and RP-UPLC-MS/MS method was established and bioanalytically validated for determining Anti depression drug sertraline in human plasma.Methods: Sertraline was extracted from human plasma by protein ...
Yasser Elshayep, waheed Salem, Abdelhameed Ismail, Fathy Abd allah   +3 more
doaj   +1 more source

Sertraline as a rare cause of interstitial lung disease [PDF]

, 2021
Sertraline, a selective serotonin reuptake inhibitor, is commonly prescribed for the treatment of moderate-to-severe depression. We report a case of a 36-year-old male taking Sertraline for seven weeks prior to developing a dry cough, pleuritic chest ...
Niall, Campbell, Lepore, Mario
core   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Granisetron-mediated augmentation of sertraline therapeutic effect in obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial

BMC Pharmacology and Toxicology, 2022
Background Medications currently recommended for the treatment of Obsessive-Compulsive Disorder (OCD) usually relieve the severity of symptoms by as much as 20–30%, and satisfactory treatment is obtained in 40–60% of patients with OCD.
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan   +7 more
doaj   +1 more source

The Preparation and Intra- and Intermolecular Addition Reactions of Acyclic N-Acylimines:  Application to the Synthesis of (±)-Sertraline

, 2016
Intramolecular endo-cyclization reactions of N-acyliminium ions have seen wide application for the synthesis of heterocyclic compounds. The corresponding exocyclic variant, which would provide 1-aminotetralin derivatives, for example, has little ...
Michael P. DeNinno (244221), John B. Etienne (3016290), Cynthia Eller (3016275)   +2 more
core   +1 more source