Results 51 to 60 of about 29,187 (219)
British Journal of Clinical Pharmacology, EarlyView.Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
wiley +1 more source
Sertraline use in pregnancy and placental transfer: A pharmacokinetic prospective cohort study
PregnancyIntroduction Depression in pregnancy is common and the use of antidepressants in pregnancy, especially sertraline, is on the rise. Although sertraline is known to cross the placenta, the level of transfer to the foetus is unclear.
Charlotte Goutallier +8 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller +9 more
wiley +1 more source
Lamotrigine toxicity secondary to sertraline
, 1998 Blood level monitoring helps to determine the therapeutic and toxic ranges for anticonvulsants and antidepressants. We investigated initial drug-drug interactions between lamotrigine and sertraline.
Kaufman, Kenneth R., Gerner, Robert
core +1 more source
Electroanalytical study of the antidepressant sertraline [PDF]
, 2005 Aflowinjection squarewave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation.
Barros, Aquiles A. +3 more
core +1 more source
PopPK modeling of sertraline (control files)
, 2022 PopPK modeling of sertraline (control files)
Milan Stoiljkovic (12957836) +3 more
core +1 more source
CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting
Clinical Pharmacology &Therapeutics, EarlyView.CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park +2 more
wiley +1 more source
Leishmanicidal mechanism of sertraline
, 2018 42 p.-8 fig.Drug repurposing affords the implementation of new treatments at a moderate cost and under a faster time-scale. Most of the clinical drugs against Leishmania share this origin.
Lima, Marta L. +7 more
core +1 more source
Drug Testing and Analysis, EarlyView.An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis +5 more
wiley +1 more source
NMDAR‐antibody encephalitis: Seizure semiology and EEG findings
Epileptic Disorders, EarlyView.Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus +6 more
wiley +1 more source