Late-life depression : issues for the general practitioner [PDF]
, 2018 Late-life depression (LLD) is both a prevalent and life-threatening disorder, affecting up to 13.3% of the elderly population. LLD can be difficult to identify because patients mainly consult their general practitioner (GP) for somatic complaints ...
Declercq, Tom +4 more
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Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, EarlyView.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
Self-limiting diarrhea in an infant exposed to sertraline in breast milk
Journal of Family Medicine and Primary Care, 2017 Sertraline is widely used to treat postpartum depression. Though studies found detectable levels of sertraline in infant blood, very few adverse effects are reported.
N A Uvais
doaj +1 more source
Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline
Brazilian Journal of Pharmaceutical Sciences, 2018 The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral ...
Mohammad Akhlaquer Rahman +1 more
doaj +1 more source
Optimal treatment for obsessive compulsive disorder:a randomized controlled feasibility study of the clinical-effectiveness and cost-effectiveness of cognitive-behavioural therapy, selective serotonin reuptake inhibitors and their combination in the management of obsessive compulsive disorder [PDF]
, 2018 Established treatments for obsessive compulsive disorder (OCD) include cognitive behaviour therapy (CBT) and selective serotonin reuptake inhibitor (SSRI) medication.
Baron-Cohen +26 more
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Phytochemical Analysis, EarlyView.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Journal of ChemistrySertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is primarily metabolized by cytochrome P450 enzymes, particularly CYP2B6, CYP2C19, and CYP3A4. However, the molecular basis of its interaction with CYP2B6 and the determinants
Sayed Ali Ahmadi +2 more
doaj +1 more source
PLoS ONE, 2014 We recently discovered that the antidepressant sertraline is an effective inhibitor of hippocampus presynaptic Na+ channel permeability in vitro and of tonic-clonic seizures in animals in vivo. Several studies indicate that the pro-inflammatory cytokines
María Sitges +2 more
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A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts
Pediatric Discovery, EarlyView.ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs are diverse and not standardized.
Emily Kim +3 more
wiley +1 more source
Oppositional Defiant Disorder and Aggression in a Young Man with Mental Retardation: Long-Term Treatment in a Community-Based Setting [PDF]
, 2008 A longitudinal, intensive treatment program is described that was implemented over an 8-year period in a community-based setting for a young man with mental retardation and oppositional defiant disorder with severe physical aggression. The development of
Barcelona, Amber L. +2 more
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