Results 61 to 70 of about 29,187 (219)

Sertraline for HIV-associated cryptococcal meningitis

, 2016
Joshua Rhein and colleagues1 used measurements of sertraline plasma concentrations and the minimum inhibitory concentrations (MICs) for sertraline to determine the probability of achieving therapeutic sertraline concentrations in the brains of patients ...
Alffenaar, Jan-Willem C., Day, Jeremy N, van der Elst, KC, Thwaites, Guy, Veringa, A, Thwaites, Guy E., van der Elst, Kim C. M., Alffenaar, JW, Veringa, Anette, Day, Jeremy N.   +9 more
core   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Chemoenzymatic Synthesis of Sertraline

, 2020
A chemoenzymatic approach has been developed for the preparation of sertraline, an established anti-depressant drug. Ketoreductases (KREDs) were employed to yield a key chiral precursor.
Marx, Lisa,, Höhne, Matthias, González‐Sabín, Javier, Morís, Francisco, Lisa Marx, Berglund, Per,, Javier González‐Sabín, Philipp Süss, Per Berglund, Süss, Philipp, Nicolás Ríos‐Lombardía, Francisco Morís, Ríos‐Lombardía, Nicolás, Matthias Höhne   +13 more
core   +1 more source

Self-limiting diarrhea in an infant exposed to sertraline in breast milk

Journal of Family Medicine and Primary Care, 2017
Sertraline is widely used to treat postpartum depression. Though studies found detectable levels of sertraline in infant blood, very few adverse effects are reported.
N A Uvais
doaj   +1 more source

Identifying patient‐centered outcomes in progressive familial intrahepatic cholestasis: Results from IMPACT

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives In rare diseases like progressive familial intrahepatic cholestasis (PFIC), lack of evidence results in treatment variability and strategies for families to engage care teams to understand how variability affects overall health are unknown.
James E. Squires, Gitta H. Lubke, Emily Ventura, Alexandra Perez, Paula M. Hertel, Emily R. Perito, Laura Bull, Melissa Kochanowsky   +7 more
wiley   +1 more source

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough

The Laryngoscope, EarlyView.
The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen, Carmen Esna, Camille Prigent, Anna Miles   +3 more
wiley   +1 more source

Structure-Based Analysis of Sertraline’s Binding Affinity With CYP2B6: An In Silico DFT and Molecular Docking Approach

Journal of Chemistry
Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is primarily metabolized by cytochrome P450 enzymes, particularly CYP2B6, CYP2C19, and CYP3A4. However, the molecular basis of its interaction with CYP2B6 and the determinants
Sayed Ali Ahmadi, Razieh Razavi, Hedyeh Tajaldini   +2 more
doaj   +1 more source

Sertraline in pregnancy - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood

, 2017
Rationale: This study is the first to measure and correlate sertraline concentrations in maternal blood, amniotic fluid and umbilical cord blood and account for distribution of the drug between these three compartments.
Gründer, Gerhard, Goecke, Tamme W., Schoretsanitis, Georgios, Stickeler, Elmar, Goecke, Tamme, Paulzen, Michael   +5 more
core   +1 more source

Sertraline Induces Toxicity and Behavioral Alterations in Planarians [PDF]

, 2017
Toxicity attributed to sertraline has been demonstrated recently in different cell types and also in some organisms. We investigated the effect of sertraline on planarians, which are considered suitable for investigations in neurotoxicology and currently
Isabela Salvador Thumé, Thumé, Isabela Salvador, Marcos Emílio Frizzo, Frizzo, Marcos Emilio dos Santos   +3 more
core   +1 more source

Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline

Brazilian Journal of Pharmaceutical Sciences, 2018
The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral ...
Mohammad Akhlaquer Rahman, Mohammad Mujahid   +1 more
doaj   +1 more source