Results 91 to 100 of about 234,177 (265)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Triglyceride-glucose index as a biochemical predictor of hypertension in patients with type 2 diabetes and prediabetes: Evidence from the NHANES database [PDF]

Journal of Medical Biochemistry
Background: The triglyceride-glucose (TyG) index, derived from fasting triglyceride and glucose levels, has emerged as a reliable biochemical marker of insulin resistance.
Dai Tianyu, Wang Fangze, Deng Hanqing, Li Muyuan, Zhang Jihu, Wang Jian   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of Atractylodes extract on growth performance， serum biochemical index， and intestinal barrier health in early-weaned piglets

Siliao yanjiu
The study aimed to explore the effect of Atractylodes extract on growth performance, serum biochemical index and intestinal barrier health in early-weaned piglets.
CHEN Bo, WANG Huan-huan, YANG Xue-xi, CHEN Lin, TAO An-xin, WANG Ya-man, LI Meng-yu, GAO Yang   +7 more
doaj  

Effect of complete pellet feed supplemented with molasses on growth performance， serum biochemical index and economic benefits of fattening mutton sheep

Siliao yanjiu, 2022
The experiment was to study the effect of self-made full price mixed pellet feed with molasses on growth performance, serum biochemical indexes and benefit of fattening mutton sheep.
Bing-lian YAN, Xiao-yan WEI, Xiao-yan LI
doaj  

Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes

陆军军医大学学报, 2022
Objective To compare and analyze the differences in the gut microbiota and serum biochemical markers between the Tibetan people in Hongyuan, and Han people in Chengdu, Sichuan Province with different body mass indexes (BMI). Methods From May 2018 to September 2019, Tibetan and Han residents from Aba Hongyuan area and Chengdu Qingbaijiang area were ...
LUO Ruocheng, HONG Zehui, ZHANG Baochao, DONG Ke   +3 more
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Effects of compound Chinese herbal medicine on serum biochemical indexes， immune， and antioxidant function in perinatal dairy cows

Siliao yanjiu
The experiment aimed to investigate the effects of compound Chinese herbal medicine on serum biochemical indexes, immune, and antioxidant function in perinatal dairy cows.
ZHANG Zhe, HAN Xuesong, HAN Jiahao, BAO Yadong, LIU Yongjun, WANG Yu   +5 more
doaj  

Effect of dietary addition of fermented apple dregs on production performance and serum biochemical index of fattening pigs

Siliao yanjiu, 2021
Effect of fermented apple drees on performance and serum indexes of finishing pigs were studied. 100 fattening pigs were divided into five groups with 20 fattening pigs in each group.
Zi-hui ZHAO, Bo-xiang CHEN, Yuan-xin LI, Wei-wei CHENG, Ming YANG, Hui-lin GUO   +5 more
doaj