Results 71 to 80 of about 464,832 (264)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Observations on the Activities of Certain Serum Enzymes and Levels of Some Biochemical Parameters in Spent Horses with Liver Damage

Notulae Scientia Biologicae, 2018
Clinical biochemistry tests are one of the tests designed to assess the functional status of the liver in domestic animals and man. This study evaluated the activities of some serum enzymes and the level of some biochemical parameters in horses with ...
Onyinyechukwu Ada AGINA, John Ikechukwu IHEDIOHA   +1 more
doaj   +1 more source

Serum biochemistry in cows of different breeds presented with reproductive conditions

Onderstepoort Journal of Veterinary Research, 2019
Minimising health problems and increasing yield have always been the objectives in livestock agriculture. Hence, increases in incidences of reproductive conditions in cattle farming pose a great threat to productivity and impose undesirable economic implications.
Molefe, Keitiretse, Mwanza, Mulunda
openaire   +5 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development of a Nano-ELISA system for the rapid and sensitive detection of H9N2 avian influenza

Archives of Razi Institute, 2016
Influenza is one of the most important viral diseases that is common among the birds and the mammals and is caused by specific viruses that belong to the Orthomyxoviridae family.
Imani Gheshlaghchaei, S., Madani, R., Golchinfar, F., Emami, T., Gholami, H.   +4 more
doaj  

High Dose of Recombinant Bovine Somatotropin Do Alter Serum Biochemical and Hormonal Profiles of Nili Ravi Buffaloes [PDF]

Pakistan Veterinary Journal, 2013
A research study was conducted to investigate the effect of high dose of recombinant bovine somatotropin (rbST) on the serum biochemical, liver enzymes and hormones of Nili Ravi buffaloes.
Tanweer Khaliq*, Zia-ur-Rahman and Ijaz Javed
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The anti-tumor efficacy of nanoparticulate form of ICD-85 versus free form

Archives of Razi Institute, 2015
Biodegradable polymeric nanoparticles (NPs) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. ICD-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit ...
Zare Mirakabadi, A., Moradhaseli, S.,, Sarzaem, A., Soheily, S., Morovati, H.   +4 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Urinary steroid profiling in diagnostic evaluation of an unusual adrenal mass

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Adrenal oncocytomas are rare tumours, with only approximately 160 cases reported in the literature. We report the use of urinary steroid profiling as part of their diagnostic evaluation and prognostication.
N F Lenders, J R Greenfield
doaj   +1 more source