Results 91 to 100 of about 135,067 (303)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Study of Serum Magnesium Levels and Its Relation to Glycemic Control in Patients with Type 2 Diabetes Mellitus [PDF]

Journal of Stress Physiology & Biochemistry, 2020
Background and objectives: Diabetes mellitus is the most common endocrine disorder and the leading cause of death and disability in the world. Magnesium is the most common intracellular cation involved in insulin mediated glucose uptake.
Ashok V., Padmini P.J.
doaj  

Low levels of serum magnesium are associated with poststroke cognitive impairment in ischemic stroke patients

, 2018
Xinjie Tu,* Huihua Qiu,* Shasha Lin, Weilei He, Guiqian Huang, Xingru Zhang, Yuemin Wu, Jincai He Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China *These authors contributed equally to this ...
Qiu H, Lin S, He J, He W, Huang G, Zhang X, Tu X, Wu Y   +7 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Magnesium and Hyaluronidase Inhibitor of Blood Serum

Experimental Biology and Medicine, 1949
SummaryMagnesium ion has been found to be essential for the hyaluronidase inhibitor activity of human blood under the conditions of the in vitro assay. The minimum amount of magnesium required for expression of maximum activity has been determined for the as-say method employed in these laboratories.
M E, FREEMAN, R, WHITNEY, A, DORFMAN
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Serum magnesium concentrations in patients receiving sodium picosulfate and magnesium citrate bowel preparation: an assessment of renal function and electrocardiographic conduction

, 2015
Gerald Bertiger,1 Edward Jones,2 David N Dahdal,3 Dennis C Marshall,3 Raymond E Joseph3 1Hillmont GI, Flourtown, PA, USA; 2Delaware Valley Nephrology and Hypertension Associates, Philadelphia, PA, USA; 3Ferring Pharmaceuticals Inc., Parsippany, NJ, USA ...
Dahdal DN, Bertiger G, Jones E, Marshall DC, Joseph RE   +4 more
core  

Concentration of magnesium in the serum and the ability status of patients with relapsing-remitting multiple sclerosis

, 2017
Multiple sclerosis (MS) is the most common autoimmune disease affecting the central nervous system, characterized by the presence of scattered foci of demyelination in the brain and spinal cord.
Socha, K., Mariak, Z., Elżbieta Karpińska, Jolanta Soroczyńska, Katarzyna Socha, Jakoniuk, M., Zenon Mariak, Maria H. Borawska, Borawska, M.H., Marta Jakoniuk, Sroczyńska, J., Kochanowicz, J., Jan Kochanowicz, Karpińska, E.   +13 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Epidermal growth factor and its influencing variables in healthy children and adults.

PLoS ONE, 2019
BACKGROUND & OBJECTIVE:Epidermal growth factor (EGF) stimulates cell proliferation and differentiation after binding to its receptor. Next to its role in magnesium homeostasis, EGF disturbances have been described in oncology, diabetes and autism ...
Sarang Meybosch, Amandine De Monie, Charlotte Anné, Luc Bruyndonckx, Angelika Jürgens, Benedicte Y De Winter, Dominique Trouet, Kristien J Ledeganck   +7 more
doaj   +1 more source