Results 201 to 210 of about 2,319,607 (308)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Screening and verification of differentially expressed serum proteins in children with severe adenovirus pneumonia. [PDF]

Front Public Health
Gao ZX, Xu H, Yang Q, Xie L, Chen LN, Liu HM.   +5 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Causal Relationships Between Dietary Habits, Gut Microbiota, Metabolites, Serum Proteins and Laboratory Biomarkers in Kidney Stone Formation: A Mendelian Randomisation Study. [PDF]

J Cell Mol Med
Wang R, Jiang M, Li Z, Xu C, Liang H, Shen J, Zhong H.   +6 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis. [PDF]

J Dent Res
Wänman M, Betnér S, Esberg A, Holm CK, Isehed C, Holmlund A, Palmqvist P, Lövgren A, Lindquist S, Hänström L, Lerner UH, Kindstedt E, Lundberg P.   +12 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Proteomic Analysis of Human Serum Proteins Adsorbed onto Collagen Barrier Membranes. [PDF]

J Funct Biomater
Shanbhag S, Al-Sharabi N, Fritz-Wallace K, Kristoffersen EK, Bunæs DF, Romandini M, Mustafa K, Sanz M, Gruber R.   +8 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Gastrointestinal health and serum proteins are associated with BMD in postmenopausal women: a cross-sectional study. [PDF]

Nutr Metab (Lond)
Wang H, Jiang Q, Yan J, Yang J, Sun J, Wang Y, Huang G, Zhang F, Cao H, Wang X, Li D.   +10 more
europepmc   +1 more source