Results 41 to 50 of about 3,187 (199)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Subgraph Query for Building Service-Based Systems

IEEE Access, 2019
Given the broad applications of service-oriented architecture (SOA) in service-oriented software engineering, service-based systems (SBSs) built from existing Web services are becoming increasingly popular.
Jintao Wu, Xing Guo, Guijun Yang, Shuhui Wu, Haseeb Hassan, Jianguo Wu   +5 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

On the Semantics of Service Compositions [PDF]

, 2007
Supporting service discovery by semantic service specifications is currently an important research area. While the approaches for the annotation of individual services are well researched, determining the semantics of compositions of services remains an open research issue.
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Practical Remediation of Hg-Contaminated Groundwater by MoS₂: Batch and Column Tests

Molecules
Trace mercury contamination in groundwater poses a serious threat to ecological systems and human health. The kinetics and isotherms of MoS2 (MS) for Hg removal were studied in batch tests under an unfavorable high salinity and low mercury environment ...
Haifeng Wang, Shuai Wei, Shuai Huang, Wei Liu, Zongwu Wang   +4 more
doaj   +1 more source

A Hybrid Service Selection and Composition Model for Cloud-Edge Computing in the Internet of Things

IEEE Access, 2020
Cloud-edge computing is a hybrid model of computing where resources and services provided via the Internet of Things (IoT) between large-scale and long-term data informs of the cloud layer and small-scale and short-term data as edge layer.
Mehdi Hosseinzadeh, Quan Thanh Tho, Saqib Ali, Amir Masoud Rahmani, Alireza Souri, Monire Norouzi, Bao Huynh   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Editorial for Special Issue “Molecular Insights into Food-Derived Natural Products and Their Biological Activities”

Current Issues in Molecular Biology
Food-derived natural products offer more than just essential nutrients like vitamins, calcium, iron, zinc, selenium, and so on [...]
Yanfang Li
doaj   +1 more source