Results 71 to 80 of about 1,725,126 (289)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Current Issues in Molecular BiologyFood-derived natural products offer more than just essential nutrients like vitamins, calcium, iron, zinc, selenium, and so on [...]
Yanfang Li
doaj +1 more source
User-centric service composition - towards personalised service composition and delivery [PDF]
, 2011 With computing devices and the Internet becoming ubiquitous, users can make use of network-based software applications in different places and situations. Mobile devices with Internet connectivity are a good example of this trend. Network-based software applications are being exposed to users as web services, which makes them accessible on demand, when
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Specification and Verification of Context-dependent Services
, 2011 Current approaches for the discovery, specification, and provision of services ignore the relationship between the service contract and the conditions in which the service can guarantee its contract.
Alagar, Vangalur +2 more
core +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
From Manual to Intelligent: A Review of Input Data Preparation Methods for Geographic Modeling
ISPRS International Journal of Geo-Information, 2019 One of the key concerns in geographic modeling is the preparation of input data that are sufficient and appropriate for models. This requires considerable time, effort, and expertise since geographic models and their application contexts are complex and ...
Zhi-Wei Hou +5 more
doaj +1 more source
Context constraint integration and validation in dynamic web service compositions [PDF]
, 2010 System architectures that cross organisational boundaries are usually implemented based on Web service technologies due to their inherent interoperability benets.
Pahl, Claus +2 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source