Results 61 to 70 of about 4,707,888 (270)

Live Piloting and Prototyping

open access: yesChallenges, 2013
This paper presents current trends in service design research concerning large scale projects aimed at generating changes at a local scale. The strategy adopted to achieve this, is to co-design solutions including future users in the development process,
Francesca Rizzo, Daria Cantù
doaj   +1 more source

Inspiring service innovation through co-design in public sector healthcare [PDF]

open access: yes, 2011
How can we inspire service innovation through the co-design of public sector healthcare delivery particularly when facing a large and complex challenge?
Macdonald, Alastair, Teal, Gemma
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Linear integrated location-inventory models for service parts logistics network design [PDF]

open access: yes, 2013
We present two integrated network design and inventory control problems in service-parts logistics systems. Such models are complicated due to demand uncertainty and highly nonlinear time-based service level constraints.
Dasci, Abdullah   +3 more
core   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Problem-Solving Design-Platform Model Based on the Methodological Distinctiveness of Service Design

open access: yesJournal of Open Innovation: Technology, Market and Complexity, 2019
This study explores the differentiated properties of service design in the context of the final value pursued by this methodology, avoiding the interpretation of pending issues to which service design is applied.
Youngok Jeon
doaj   +1 more source

Exploring the value of a design for service approach to develop public services in the Community Voluntary Sector: a comparative analysis [PDF]

open access: yes, 2014
This paper presents the findings from two action research case studies that explore the value of using a ‘design for service’ approach to develop public services in the community voluntary sector (CVS).
Lievesley, Matthew   +2 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

DESIGN TOOLS FOR LIFE CYCLE ANALYSIS AND DURABILITY EVALUATION OF BUILDING SYSTEMS: A RESEARCH ON THE BUILDING ENVELOPE [PDF]

open access: yes, 2013
The behavior and service life prediction of building systems requires to develop tools to assist the designer. The paper is focused on a research carried out in the Department of Architecture and Design with the Department of Mathematical Sciences of the
Levra Levron, Andrea   +2 more
core  

Developing Technological Pedagogical Content Knowledge in pre-service science teachers: Support from blended learning [PDF]

open access: yes, 2012
The Technological Pedagogical Content Knowledge (TPACK) framework has been used to prepare pre-service science teachers at the Public Authority of Applied Education and Training in Kuwait for ICT integration in education.
Alayyar, G., Fisser, P., Voogt, Joke
core   +2 more sources

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