Results 71 to 80 of about 4,754,432 (291)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Live Piloting and Prototyping

Challenges, 2013
This paper presents current trends in service design research concerning large scale projects aimed at generating changes at a local scale. The strategy adopted to achieve this, is to co-design solutions including future users in the development process,
Francesca Rizzo, Daria Cantù
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Exploring the UK high street retail experience: is the service encounter still valued? [PDF]

, 2014
Purpose: The relationship between service quality, the service encounter and the retail experience is explored within a changing UK retail environment. Design: Data was gathered from forty customers and twenty staff of an established UK health and ...
Foster, C, Resnick, S, Woodall, T
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Problem-Solving Design-Platform Model Based on the Methodological Distinctiveness of Service Design

Journal of Open Innovation: Technology, Market and Complexity, 2019
This study explores the differentiated properties of service design in the context of the final value pursued by this methodology, avoiding the interpretation of pending issues to which service design is applied.
Youngok Jeon
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Analysis of User Experience in the WEVERSE Application using the ITIL V3 Service Design Domain : An ENGENE Perspective in Indonesia

Sistemasi: Jurnal Sistem Informasi
The rapid development of digital technology has changed the way artists and fans interact through community applications such as Weverse. This study aims to evaluate the user experience of Weverse from the perspective of ENGENE (ENHYPEN fans) in ...
Emmanuela Adtrisel Saudale, Penidas Fiodinggo Tanaem   +1 more
doaj   +1 more source

INCLUSIVE APPROACH OUTCOMES IN DEVELOPMENT PROJECTS FOR CULTURAL AND LINGUISTIC MINORITIES – AN INTERVIEW STUDY [PDF]

Psychiatria Fennica, 2023
A Finnish initiative called TUULI project, led by the Finnish Institute for Health and Welfare, was launched in 2019 to respond to the need of providing accessible psychoeducational material for newly arrived refugees and for professionals working ...
Niina Porta, Antti Klemettilä, Sari Fröjd, Anu E. Castaneda   +3 more
doaj  

‘One big wheel’: young people’s participation in service, design, development and delivery (Sharing our experience, Practitioner-led research 2008-2009; PLR0809/080) [PDF]

, 2009
How do professionals and agencies seek the views of young people moving from participation to the implementation of service design and delivery? The research involved six white British young people from the Camborne, Pool and Redruth (CPR) area of ...
James, Natasha
core