Results 81 to 90 of about 699,193 (339)

OpenRASE: Service Function Chain Emulation

open access: yes2025 International Conference on Software, Telecommunications and Computer Networks (SoftCOM)
Service Function Chains (SFCs) are one of the key enablers in providing programmable computer networks, paving the way for network autonomy. However, this also introduces new challenges, such as resource allocation and optimisation related to their operation, requiring new algorithms to address these challenges.
Krishnamohan, Theviyanthan, Harvey, Paul
openaire   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Potential field based navigation for planetary rovers using internal states [PDF]

open access: yes, 2008
The work in this paper aims to introduce analysis and applications for the internal state model which is a new model for a swarm of rovers interacting via pair-wise attractive and repulsive potentials.
Abdel Wahid, Mohamed Hussien Mabrouk   +1 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

NLSC: Unrestricted Natural Language-based Service Composition through Sentence Embeddings

open access: yes, 2019
Current approaches for service composition (assemblies of atomic services) require developers to use: (a) domain-specific semantics to formalize services that restrict the vocabulary for their descriptions, and (b) translation mechanisms for service ...
Akoju, Sushma A.   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Optimal Execution of Virtualized Network Functions for Applications in Cyber-Physical-Social-Systems

open access: yesIEEE Access, 2018
Cyber-physical-social systems exploit the relationship between humans, computers, and the physical environment to provide high-quality real-time and personalized services.
Rofiqul Islam   +5 more
doaj   +1 more source

Discovering, quantifying, and displaying attacks

open access: yes, 2016
In the design of software and cyber-physical systems, security is often perceived as a qualitative need, but can only be attained quantitatively. Especially when distributed components are involved, it is hard to predict and confront all possible attacks.
Nielson, Flemming   +2 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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