Results 61 to 70 of about 1,735,027 (279)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The role of network ties in reaching radical innovation [PDF]

, 2018
The purpose of this paper is to analyze how institutions can facilitate or inhibit radical innovation. The authors maintain that organizational radical innovation is necessary to maintain a competitive advantage and evolve in the market place, and ...
Quero-Gervilla, Maria Jose, Ventura-Fernández, Rafael   +1 more
core  

The UK National Health Service’s 'innovation agenda': lessons on commercialization and trust [PDF]

, 2014
The UK National Health Service (the 'NHS'), encouraged by the 2011 report Innovation Health and Wealth, Accelerating Adoption and Diffusion in the NHS, and empowered by the Health and Social Care Act 2012, is in the process of adopting a new agenda for ...
Cockbain, Julian, Sterckx, Sigrid
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Towards a framework for New Service Development Practices

Journal of Innovation Management, 2017
Different frameworks for New Service Development (NSD) practices have been suggested by prior conceptual research. We have assessed three frameworks frequently referred to in extant research, and exposed how these three cover different dimensions of NSD ...
Katja Maria Hydle, Tor Helge Aas, Karl Joachim Breunig   +2 more
doaj   +1 more source

SERVICE BUSINESS MODEL AND SERVICE INNOVATIVENESS [PDF]

International Journal of Innovation Management, 2014
Service innovativeness has been hailed as a key success factor in being able to differentiate a new service from its competing offerings. In spite of a number of literatures suggesting the impact that a service business model can have on service innovativeness, no comprehensive and empirical study has examined the relationship between the distinctive ...
COLIN C. J. CHENG, ERIC C. C. SHIU, JOHN A. DAWSON   +2 more
openaire   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Developing company competitiveness based on entrepreneurial values, transformational leadership, and service innovation through organizational performance

JPPI (Jurnal Penelitian Pendidikan Indonesia)
Company competitiveness is very important for business continuity. Therefore, the research aims to investigate and find an empirical model of the influence of entrepreneurial values, transformational leadership, and service innovation on company ...
Solikin Solikin, Muhammad Thamrin, Suharto Abdul Majid, Librita Arifiani   +3 more
doaj   +1 more source

Service Innovations in the Healthcare Service Ecosystem: A Case Study

Systems, 2017
In the service economy, scholars and practitioners are even more focused on the development and appliance of innovative services. The importance of service innovation is rising in many sectors and among different organizations. Several disciplines (e.g.,
Maria V. Ciasullo, Silvia Cosimato, Marco Pellicano   +2 more
doaj   +1 more source