Results 71 to 80 of about 33,086,186 (300)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Service Science: A Reflection from Telecommunications Service Perspective

, 2010
An initial set of requirements for a proposed next-generationtelecom service innovation model is derived by viewing telecommunications service in the context of the emergentservice science principles.
Chew, EK
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Announcing a correspondence course on leadership : a project of the Virginia Cooperative Extension Service

, 1983
A brochure announcing a new correspondence course offered through the Cooperative Extension ...
Virginia Cooperative Extension Service
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Science teacher education in Malaysia: challenges and way forward

Asia-Pacific Science Education, 2018
This concept paper discussed the development of science teacher education programs in Malaysia. The discussion encompassed the existing policies, practices and issues, arising from the science teacher education.
Siti Nur Diyana Mahmud, Nurfaradilla Mohamad Nasri, Mohd Ali Samsudin, Lilia Halim   +3 more
doaj   +1 more source

An Experience-based Collaborative Service System Model

, 2017
Our aim in this paper is to develop a specialized model of service engagement in the design of services. We build on some widely accepted constructions of service science that have appeared in the literature to produce a model that is relevant and ...
Ananth Srinivasan, Lesley Gardner, Arzoo Atiq, Atiq, A, Gardner, LA, Srinivasan, A   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Academic Achievement and Postgraduate Career Commitment among Pre-Service Teachers: The Mediating Role of Science Identity

Current Issues in Education
This cross-sectional study investigated the relationship between academic achievement (measured by GPA) and a science-related psychological variable, science identity, in higher education.
ilhan ilter, Stefan Rathert
doaj   +1 more source

Institutional Complexity as a Driver for Innovation in Service Ecosystems

, 2016
This paper extends research on innovation as institutional change within service science and service-dominant (S-D) logic by conceptualizing the emergence of novel solutions in service ecosystems.
Vargo, Stephen L.,, Siltaloppi, Jaakko,, Koskela-Huotari, Kaisa,   +2 more
core   +1 more source