Results 71 to 80 of about 4,823,824 (296)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Leveraging Service Science for Strategic Marketing: A Case Study of a Canadian Mattress Company [PDF]
ITM Web of ConferencesThis study utilizes a service science perspective to elaborate on the strategic marketing plan of a Canadian mattress company. Founded in 2014, the company has transformed the mattress industry’s traditional product-centric paradigm by adopting a service-
Menvielle William +2 more
doaj +1 more source
A conceptual model of service exchange in service-dominant logic [PDF]
, 2010 The service system is the basic abstraction of Service Science. This paper proposes the Resource-Service-System model as a conceptual model of service systems interacting in service exchanges, assuming a service-dominant logic economic worldview.
Poels, Geert
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Science teacher education in Malaysia: challenges and way forward
Asia-Pacific Science Education, 2018 This concept paper discussed the development of science teacher education programs in Malaysia. The discussion encompassed the existing policies, practices and issues, arising from the science teacher education.
Siti Nur Diyana Mahmud +3 more
doaj +1 more source
SOCIAL SCIENCE IN THE EXTENSION SERVICE [PDF]
Teaching/Communication/Extension/Profession,
Miller, Paul A.
core +1 more source
Experimental Design at the Intersection of Mathematics, Science, and Technology in Grades K-6 [PDF]
, 1999 Interdisciplinary courses, highlighting as they do the area(s) the disciplines have in common, often give the misperception of a single body of knowledge and/or way of knowing.
Giese, R N., Mason, M. M.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Using Technology as a Vehicle to Appropriately Integrate Mathematics and Science Instruction for the Middle School [PDF]
, 1999 At the College of William and Mary, pre-service middle school science and mathematics teachers enroll in their respective methods courses taught in the same time period.
Giese, R. N., Mason, M. M.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source