Results 41 to 50 of about 5,356,878 (308)

The impact of donor transition on continuity of maternal and newborn health service delivery in Rwenzori sub-region of Uganda: a qualitative country case study analysis

Globalization and Health, 2023
Background The transition of donor-supported health programmes to country ownership is gaining increasing attention due to reduced development assistance for health globally.
Eric Ssegujja, Justine Namakula, Allen Kabagenyi, Carol Kyozira, Timothy Musila, Henry Zakumumpa, Freddie Ssengooba   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Health-related quality of life and self-reported health status in adolescents with chronic health conditions before transfer of care to adult health care: an international cohort study

BMC Pediatrics
Background Heath-related quality of life (HRQoL) is lower in adolescents with chronic health conditions compared to healthy peers. While there is evidence of some differences according to the underlying condition and gender, differences by measure and ...
Mira Kallio, Anna Tornivuori, Päivi J. Miettinen, Kaija-Leena Kolho, Heikki Relas, Evelyn Culnane, Hayley Loftus, Susan M. Sawyer, Silja Kosola   +8 more
doaj   +1 more source

Utilisation du modèle hydrodynamique 1D Mascaret pour la prévision des crues

LHB Hydroscience Journal
Le code de modélisation hydraulique monodimensionnelle Mascaret, développé à partir des années 1990, s’est progressivement modernisé et est désormais maintenu dans le cadre du Consortium TELEMAC-MASCARET (cf.
Etienne Le Pape, Matthieu Nicolas, Alexis Bernard, Matthieu De Linares, Mehdi Pierre Daou   +4 more
doaj   +1 more source

A longitudinal, observational study of the features of transitional healthcare associated with better outcomes for young people with long-term conditions

BMC Medicine, 2018
Background Most evidence about what works in transitional care comes from small studies in single clinical specialties. We tested the hypothesis that exposures to nine recommended features of transitional healthcare were associated with better outcomes ...
A. Colver, H. McConachie, A. Le Couteur, G. Dovey-Pearce, K. D. Mann, J. E. McDonagh, M. S. Pearce, L. Vale, H. Merrick, J. R. Parr, On behalf of the Transition Collaborative Group   +10 more
doaj   +1 more source

Transitional Pain Service: An Update

Current Pain and Headache Reports
Abstract Purpose of Review Chronic Postsurgical Pain (CPSP) and the risk for long-term opioid dependency are known complications following major surgery. The idea of Transitional Pain Service (TPS) has been introduced as an interdisciplinary setting to manage pain in the perioperative continuum.
Roman Klimke, Alexander Ott, Carolina S. Romero, Andrea Berendes, Richard D. Urman, Markus M. Luedi, Vighnesh Ashok   +6 more
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Service Network Fleet Transition Problem

Transport Economics and Management
The road freight sector is a large source of carbon emissions yet notoriously hard to decarbonize. Logistics service providers and fleet operators face increasing pressure to adopt and implement carbon emissions reduction targets over the next years and ...
Jonas Lehmann, Anne Gvozdjak, Matthias Winkenbach   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source