Results 51 to 60 of about 5,356,878 (308)

Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18

BMJ Open, 2020
IntroductionTransition between health services is widely recognised as a problematic hurdle. Yet, the factors necessary for successful transition out of child and adolescent mental health services (CAMHS) as youth reach the service boundary at age 18 are
Amy Cheung, Jennifer Stinson, Andrea Levinson, Antonio Pignatiello, Aristotle N Voineskos   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Announcing a correspondence course on leadership : a project of the Virginia Cooperative Extension Service

, 1983
A brochure announcing a new correspondence course offered through the Cooperative Extension ...
Virginia Cooperative Extension Service
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Firms' transition towards green product service system innovators [PDF]

Within this paper we explore transition paths firms can take to become product service system (PSS) innovators. Applying the dynamic capability approach we study how three firms have developed PSS innovations in the mobility sector (Car2Go by Daimler AG,
Tietze, Frank, Schiederig, Tim, Herstatt, Cornelius   +2 more
core  

Service Evaluation of Transition Pathway and Audit of National Institute of Clinical Excellence (NICE) Guidelines Compliance

BJPsych Open
Aims: This project aimed to evaluate our transition service for young people, from Child & Adolescent Service (CAMHS) to Adult Mental Health Services (AMHS), and to audit NICE transition guidelines compliance.
Umama Khan, Basanta Sapkota, Parvathy Suresh, Amaia Del-Pozo-Ugalde, Jeremy Turk   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

The Avahan Transition: Effects of Transition Readiness on Program Institutionalization and Sustained Outcomes.

PLoS ONE, 2016
BackgroundWith declines in development assistance for health and growing interest in country ownership, donors are increasingly faced with the task of transitioning health programs to local actors towards a path to sustainability.
Sachiko Ozawa, Suneeta Singh, Kriti Singh, Vibha Chhabra, Sara Bennett   +4 more
doaj   +1 more source

Early Psychosis Intervention-Spreading Evidence-based Treatment (EPI-SET): protocol for an effectiveness-implementation study of a structured model of care for psychosis in youth and emerging adults

BMJ Open, 2020
Introduction While early psychosis intervention (EPI) has proliferated in recent years amid evidence of its effectiveness, programmes often struggle to deliver consistent, recovery-based care.
Sophie Soklaridis, Paul Kurdyak, Claire de Oliveira, Simone Dahrouge, Joanna Henderson, Aristotle N Voineskos, Kelly K Anderson, Nicole Kozloff, George Foussias, Janet Durbin, Sanjeev Sockalingam, Jean Addington, Donald Addington, Augustina Ampofo, Melanie Barwick, Sarah Bromley, Jasmyn E A Cunningham, Lillian Duda, Catherine Ford, Sheila Gallagher, John D Haltigan, Alexia Jaouich, Dielle Miranda, Patrick Mitchell, Josette Morin, Valerie Primeau, Eva Serhal, Diana Urajnik, Krista Whittard, Juveria Zaheer   +29 more
doaj   +1 more source