Results 71 to 80 of about 6,224,123 (241)
BMC PsychiatryBackground Mental health rehabilitation services provide specialist treatment to people with particularly severe and complex problems. In 2018, the Care Quality Commission reported that over half the 4,400 mental health inpatient rehabilitation beds in ...
Helen Killaspy +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Frontiers in PsychiatryIntroductionMental health is influenced by how we perceive ourselves and others. A person’s conceptual structure and how he/she understands and makes sense of the world can be explored using the repertory grid technique (RGT), an assessment tool derived ...
Eleanor Elizabeth Wozniak +7 more
doaj +1 more source
A Survey of User Profiling: State-of-the-Art, Challenges, and Solutions
IEEE Access, 2019 Advancements in information and communication technology, and online web users have given attention to the virtual representation of each user, which is crucial for effective service personalization.
Christopher Ifeanyi Eke +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Accounting for Research – the Difficulties Posed for User-Centred Research [PDF]
, 2006 When public money is invested in research it is necessary to have in place accounting systems that demonstrate its value. By this we mean its social as much as its economic value to society.
Minogue, Virginia +6 more
core +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The impact of user fees on health service utilization in low- and middle-income countries: how strong is the evidence? [PDF]
, 2008 OBJECTIVE: To assess the effects of user charges on the uptake of health services in low- and middle-income countries. METHODS: A systematic search of 25 social science, economics and health literature databases and other sources was performed to ...
Palmer, Natasha, Lagarde, Mylene
core +1 more source
Service Selection With QoS Correlations in Distributed Service-Based Systems
IEEE Access, 2019 Service selection is an important research problem in distributed service-based systems, which aims to select proper services to meet user requirements. A number of service selection approaches have been proposed in recent years.
Dongwei Li +3 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source