Results 71 to 80 of about 6,440,715 (300)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A Framework for Design and Composition of Semantic Web Services [PDF]

, 2004
Semantic Web Services (SWS) are Web Services (WS) whose description is semantically enhanced with markup languages (e.g., OWL-S). This semantic description will enable external agents and programs to discover, compose and invoke SWSs.
Manuel Lama, Asunción Gómez-pérez, Rafael González-cabero, González-Cabero, R., Gómez-Pérez, A., Lama, M.   +5 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

User-Generated Services Composition in Smart Multi-User Environments

Journal of Sensor and Actuator Networks, 2017
The increasing complexity shown in Smart Environments, together with the spread of social networks, is increasingly moving the role of users from simple information and services consumers to actual producers.
Vincenzo Catania, Giuseppe La Torre, Salvatore Monteleone, Daniela Panno, Davide Patti   +4 more
doaj   +1 more source

Service Composition in Stochastic Settings [PDF]

, 2017
With the growth of the Internet-of-Things and online Web services, more services with more capabilities are available to us. The ability to generate new, more useful services from existing ones has been the focus of much research for over a decade. The goal is, given a specification of the behavior of the target service, to build a controller, known as
Ronen I. Brafman, Giuseppe De Giacomo, Massimo Mecella, Sebastian Sardiña   +3 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Automatic discovery and composition of semantic web services using AI planning and web service modeling ontology [PDF]

, 2009
In order to realize Service Oriented Architecture computing, Web services are the preferred standards-based way. One of the recent critical issues is automated composition of Web services. A number of approaches have been proposed to resolve the problem.
Wan Kadir, Wan Mohd. Nasir, Tabatabaei, Sayed Gholam Hassan, Ibrahim, Suhaimi   +2 more
core   +1 more source

Approaches to Semantic Web Services: An Overview and Comparison [PDF]

, 2004
. The next Web generation promises to deliver Semantic Web Services (SWS); services that are self-described and amenable to automated discovery, composition and invocation.
Terry Payne, Payne, Terry R., Sereno, Bertrand, Uren, Victoria, Simon Buckingham Shum, Payne, Terry, Enrico Motta, Farshad Hakimpour, Victoria Uren, John Domingue, Buckingham Shum, Simon, Domingue, John, Hakimpour, Farshad, Liliana Cabral, Bertrand Sereno, Cabral, Liliana, Motta, Enrico   +16 more
core   +2 more sources