Results 41 to 50 of about 89,136 (367)

Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway

Frontiers in Pharmacology, 2022
Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene.
Qing Rao, Qing Rao, Kaiqiang Xie, Kaiqiang Xie, Krishnapriya M. Varier, Krishnapriya M. Varier, Krishnapriya M. Varier, Lei Huang, Lei Huang, Jingrui Song, Jingrui Song, Jue Yang, Jue Yang, Jianfei Qiu, Jianfei Qiu, Yubing Huang, Yubing Huang, Yan Li, Yan Li, Babu Gajendran, Babu Gajendran, Babu Gajendran, Yanmei Li, Yanmei Li, Sheng Liu, Sheng Liu   +25 more
doaj   +1 more source

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

, 2019
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn’t psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1).
F. Francomano, A. Caruso, A. Barbarossa, Alessia Fazio, Chiara La Torre, Jessica Ceramella, R. Mallamaci, C. Saturnino, Domenico Iacopetta, M. Sinicropi   +9 more
semanticscholar   +1 more source

Reactivity and Biological Activity of the Marine Sesquiterpene Hydroquinone Avarol and Related Compounds from Sponges of the Order Dictyoceratida

Molecules, 2006
A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo- rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples
Miroslav J. Gasic, Dusan Sladic
doaj   +1 more source

Xanthium strumarium - a potential cheap resource of plant substances for medicinal use [PDF]

, 2019
Xanthium strumarium L. (Asteraceae) is an annual herb which reproduces solely by seed. So far its centre of origin was considered Central or South America. Recent archeological research revealed that the burs of X.
Ionkova I., Kozuharova E., Spadaro V.
core   +1 more source

(1S,3R,8R,11S)-2,2,11-Tribromo-10-bromomethyl-3,7,7-trimethyltricyclo[6.4.0.01,3]dodec-9-ene

IUCrData, 2016
The title compound, C16H22Br4, was synthesized in two steps from β-himachalene, which was isolated from essential oil of the Atlas cedar (cedrus atlantica).
Abdoullah Bimoussa, Aziz Auhmani, My Youssef Ait Itto, Jean-Claude Daran, Abdelwahed Auhmani   +4 more
doaj   +1 more source

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Investigating the antiparasitic potential of the marine sesquiterpene avarone, its reduced form avarol, and the novel semisynthetic thiazinoquinone analogue thiazoavarone [PDF]

, 2020
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
AIELLO, ANNA, Avunduk, Sibel, Basilico, Nicoletta, CASERTANO, MARCELLO, FATTORUSSO, CATERINA, Gimmelli, Roberto, Guidi, Alessandra, IMPERATORE, CONCETTA, LUCIANO, PAOLO, MENNA, MARIALUISA, Parapini, Silvia, PERSICO, MARCO, Ruberti, Giovina, Saccoccia, Fulvio   +13 more
core   +1 more source

The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna

Molecules, 2015
The present study reports a bioassay-guided isolation of β-caryophyllene from the essential oil of Aquilaria crassna. The structure of β-caryophyllene was confirmed using FT-IR, NMR and MS.
S. Dahham, Y. Tabana, M. Iqbal, M. K. Ahamed, M. Ezzat, A. S. A. Majid, A. Majid   +6 more
semanticscholar   +1 more source

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin‐Dependent Monooxygenase in Lasalocid A Biosynthesis

Angewandte Chemie, EarlyView.
Lsd18 is a flavin‐dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X‐ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.
Qian Wang, Yaming Deng, Dayan Viera, Xiaopeng Liu, Ning Liu, Yulu Hu, Xiangdong Hu, Hao Wei, Quan Zhou, Ting Lan, Wei He, Xi Chen, Chu‐Young Kim   +12 more
wiley   +2 more sources

Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities

Molecules, 2016
Nerolidol (3,7,11-trimethyl-1,6,10-dodecatrien-3-ol) is a naturally occurring sesquiterpene alcohol that is present in various plants with a floral odor.
Weng-Keong Chan, Loh Teng-Hern Tan, Kok-Gan Chan, Learn‐Han Lee, B. Goh   +4 more
semanticscholar   +1 more source