Results 71 to 80 of about 8,228 (244)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The pointwise limit of metric integral operators approximating set-valued functions
, 2023 For set-valued functions (SVFs, multifunctions), mapping a compact interval $[a,b]$ into the space of compact non-empty subsets of ${\mathbb R}^d$, we study approximation based on the metric approach that includes metric linear combinations, metric selections and weighted metric integrals.
Berdysheva, Elena E. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
IEEE Access, 2019 In multi-criteria decision making (MCDM), it is difficult for decision-makers to give accurate evaluation values, and one-dimensional fuzzy set theory cannot capture periodic and seasonal information.
Jian-Ping Fan, Rui Cheng, Mei-Qin Wu
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
IEEE Access, 2019 Considering decision makers (DMs) maybe hesitant among a set of values when determining the membership and non-membership degrees in a q-rung orthopair fuzzy environment, the q-rung dual hesitant fuzzy sets (q-RDHFS) were proposed.
Yuan Xu +5 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
On Lower Semicontinuity and Metric Upper Semicontinuity of Nemytskii Set-Valued Operators
Zeitschrift für Analysis und ihre Anwendungen, 1994 Sufficient conditions of lower semicontinuity and metric upper semicontinuity of Nemytskii set-valued operators N_F generated by a set-valued function F: \Omega \times X \to 2^Y
Rolewicz, S., Wen, Song
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source